Academic Journal
Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis
| العنوان: | Genetics, diet, microbiota, and metabolome: partners in crime for colon carcinogenesis |
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| المؤلفون: | La Vecchia M., Sala G., Sculco M., Aspesi A., Dianzani I. |
| المساهمون: | La Vecchia, M., Sala, G., Sculco, M., Aspesi, A., Dianzani, I. |
| سنة النشر: | 2024 |
| المجموعة: | Università degli Studi del Piemonte Orientale: CINECA IRIS |
| مصطلحات موضوعية: | Colorectal cancer, Diet, Gut metabolome, Gut microbiota, Inherited predisposition, Obesity, Risk factors |
| الوصف: | Colorectal cancer (CRC) ranks among the most prevalent malignant tumors worldwide, with a multifactorial etiology encompassing genetic, environmental, and life-style factors, as well as the intestinal microbiota and its metabolome. These risk factors often work together in specific groups of patients, influencing how CRC develops and progresses. Importantly, alterations in the gut microbiota act as a critical nexus in this interplay, significantly affecting susceptibility to CRC. This review highlights recent insights into unmodifiable and modifiable risk factors for CRC and how they might interact with the gut microbiota and its metabolome. Understanding the mechanisms of these interactions will help us develop targeted, precision-medicine strategies that can adjust the composition of the gut microbiota to meet individual health needs, preventing or treating CRC more effectively. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39470880; info:eu-repo/semantics/altIdentifier/wos/WOS:001344812700001; volume:24; issue:1; journal:CLINICAL AND EXPERIMENTAL MEDICINE; https://hdl.handle.net/11579/194422 |
| DOI: | 10.1007/s10238-024-01505-x |
| الاتاحة: | https://hdl.handle.net/11579/194422 https://doi.org/10.1007/s10238-024-01505-x |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DF192DDA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10238-024-01505-x |
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