Conference
Smart flexible planar electrodes for electrochemotherapy and biosensing
| العنوان: | Smart flexible planar electrodes for electrochemotherapy and biosensing |
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| المؤلفون: | NENZI, Paolo, DENZI, AGNESE, KHOLOSTOV, KONSTANTIN, CRESCENZI, Rocco, APOLLONIO, Francesca, LIBERTI, Micaela, MARRACINO, PAOLO, Alessia Ongaro, Ruggero Cadossi, BALUCANI, Marco |
| المساهمون: | Nenzi, Paolo, Denzi, Agnese, Kholostov, Konstantin, Crescenzi, Rocco, Apollonio, Francesca, Liberti, Micaela, Marracino, Paolo, Alessia, Ongaro, Ruggero, Cadossi, Balucani, Marco |
| بيانات النشر: | IEEE |
| سنة النشر: | 2013 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | electrochemotherapy, electroporation, gene electrotransfer |
| الوصف: | Electroporationis an effective method to deliver drugs into tumor cells to kill them, by applying a pulsed electric field to the cellular membrane [1, 2]. Existing electrodes consist of clamping claws or arrays of needles and can be effectively applied only to small areas. New electrodes that can treat large areas are sought; flexibility is needed to adapt to irregular tumor shape and, to be folded to enter from small surgical opening. In this work we present the design and test of a 16 cm2 flexible electrode for electroporation with biosensing capabilities, built with standard flexible circuit technologies enclosed in a biocompatible package. The electrode contains electronics to provide cryptography-based identification to the electroporation machine to avoid setup errors and protection against use of counterfeited electrodes. In-vitro tests of the electrode show that electroporation occurs up to a depth of 8 mm with 100% electroporation efficiency over the 30% of electrode area. Temperature rise on the electrode during treatment does not exceed 6 degrees celsius, a value that not causes damage to the cells. © 2013 IEEE. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isbn/9781479902323; info:eu-repo/semantics/altIdentifier/isbn/9781479902330; info:eu-repo/semantics/altIdentifier/wos/WOS:000332764900074; ispartofbook:Proceedings - Electronic Components and Technology Conference; 2013 IEEE 63rd Electronic Components and Technology Conference, ECTC 2013; volume:2013; firstpage:486; lastpage:493; numberofpages:8; http://hdl.handle.net/11573/530187; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84883430987 |
| DOI: | 10.1109/ectc.2013.6575616 |
| الاتاحة: | http://hdl.handle.net/11573/530187 https://doi.org/10.1109/ectc.2013.6575616 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.DF18BAF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1109/ectc.2013.6575616 |
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