Academic Journal
P16 Cutoff in Head and Neck Squamous Cell Carcinoma: Correlation between Tumor and Patient Characteristics and Outcome
| العنوان: | P16 Cutoff in Head and Neck Squamous Cell Carcinoma: Correlation between Tumor and Patient Characteristics and Outcome |
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| المؤلفون: | Merlano, Marco Carlo, Denaro, Nerina, Vivenza, Daniela, Monteverde, Martino, Russi, Elvio, Lerda, Walter, Comino, Alberto, Lo Nigro, Cristiana |
| المصدر: | The International Journal of Biological Markers ; volume 31, issue 1, page 44-52 ; ISSN 0393-6155 1724-6008 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2016 |
| الوصف: | Background p16 has been indicated as a suitable surrogate biomarker of HPV infection. The prognosis of p16-positive oropharynx tumors (OTs) of squamous cell carcinoma (SCC) histology is better than that of p16-negative tumors. Methods We analyzed 209 samples of head and neck SCC to establish a predictive cutoff for p16 and determine the role of p16 positivity in OTs versus non-OTs. We compared the outcomes of tumors harboring any percentage of p16-positive cells (≥1%) with those of p16-negative OTs. We then considered 3 cutoffs (10%, 50% and 70% positive cells) to evaluate the outcome of OTs/non-OTs with similar p16 expression and p16-positive versus p16-negative tumors stratified by patient age. Results p16-negative tumors among OTs and non-OTs were 29% and 49%, respectively (p = 0.0054). The cumulative distribution showed that the positive values were located around 2 focus points: 2% and 96%. Subgroup analysis showed that only OTs occurred in young patients (aged <65 years) and that there was a ≥70% gain in survival in cases with p16-positive cells. Conclusions p16 positivity influences outcome only in young patients and OTs (p = 0.048). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.5301/jbm.5000175 |
| الاتاحة: | https://doi.org/10.5301/jbm.5000175 https://journals.sagepub.com/doi/pdf/10.5301/jbm.5000175 https://journals.sagepub.com/doi/full-xml/10.5301/jbm.5000175 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.DF05B4FC |
| قاعدة البيانات: | BASE |
| DOI: | 10.5301/jbm.5000175 |
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