Academic Journal
Processing of carbon-reinforced construction materials releases PM 2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts.
| العنوان: | Processing of carbon-reinforced construction materials releases PM 2.5 inducing inflammation and (secondary) genotoxicity in human lung epithelial cells and fibroblasts. |
|---|---|
| المؤلفون: | Pantzke, J., Koch, A., Zimmermann, E., Rastak, N., Offer, S., Bisig, B., Bauer, S., Oeder, S., Orasche, J., Fiala, P., Stintz, M., Rüger, C., Streibel, T., Di Bucchianico, S., Zimmermann, R. |
| المصدر: | Environ. Toxicol. Pharmacol. 98:104079 (2023) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | PuSH - Publikationsserver des Helmholtz Zentrums München |
| مصطلحات موضوعية: | Air-liquid Interface, Bisphenol A, Carbon Fibre Toxicity, Polycyclic Aromatic Hydrocarbons, Transcriptome |
| الوصف: | Building demolition following domestic fires or abrasive processing after thermal recycling can release particles harmful for the environment and human health. To mimic such situations, particles release during dry-cutting of construction materials was investigated. A reinforcement material consisting of carbon rods (CR), carbon concrete composite (C³) and thermally treated C³(ttC³) were physicochemically and toxicologically analyzed in monocultured lung epithelial cells, and co-cultured lung epithelial cells and fibroblasts at the air-liquid interface. C³particles reduced their diameter to WHO fibre dimensions during thermal treatment. Caused by physical properties or by polycyclic aromatic hydrocarbons and bisphenol A found in the materials, especially the released particles of CR and ttC³induced an acute inflammatory response and (secondary) DNA damage. Transcriptome analysis indicated that CR and ttC³particles carried out their toxicity via different mechanisms. While ttC³affected pro-fibrotic pathways, CR was mostly involved in DNA damage response and in pro-oncogenic signaling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36796551; info:eu-repo/semantics/altIdentifier/wos/000967151900001; info:eu-repo/semantics/altIdentifier/isbn/1382-6689; info:eu-repo/semantics/alt |
| DOI: | 10.1016/j.etap.2023.104079 |
| الاتاحة: | https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=67465 https://doi.org/10.1016/j.etap.2023.104079 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.DEFBBAB0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.etap.2023.104079 |
|---|