Academic Journal

Contributions of gonadal hormones in the sex-specific organization of context fear learning

التفاصيل البيبلوغرافية
العنوان: Contributions of gonadal hormones in the sex-specific organization of context fear learning
المؤلفون: Colón, Lorianna, Peru, Eduardo, Zuloaga, Damian G., Poulos, Andrew M.
المساهمون: Cooper, Brenton G., Foundation for the National Institutes of Health
المصدر: PLOS ONE ; volume 18, issue 3, page e0282293 ; ISSN 1932-6203
بيانات النشر: Public Library of Science (PLoS)
سنة النشر: 2023
المجموعة: PLOS Publications (via CrossRef)
الوصف: It is widely established that gonadal hormones are fundamental to modulating and organizing the sex-specific nature of reproductive behaviors. Recently we proposed that context fear conditioning (CFC) may emerge in a sex-specific manner organized prior to the pubertal surge of gonadal hormones. Here we sought to determine the necessity of male and female gonadal hormones secreted at critical periods of development upon context fear learning. We tested the organizational hypothesis that neonatal and pubertal gonadal hormones play a permanent role in organizing contextual fear learning. We demonstrate that the postnatal absence of gonadal hormones by neonatal orchiectomy (oRX) in males and ovariectomy (oVX) in females resulted in an attenuation of CFC in adult males and an enhancement of CFC in adult females. In females, the gradual introduction of estrogen before conditioning partially rescued this effect. However, the decrease of CFC in adult males was not rescued by introducing testosterone before conditioning. Next, at a further point in development, preventing the pubertal surge of gonadal hormones by prepubertal oRX in males resulted in a reduction in adult CFC. In contrast, in females, prepubertal oVX did not alter adult CFC. However, the adult introduction of estrogen in prepubertal oVX rats reduced adult CFC. Lastly, the adult-specific deletion of gonadal hormones by adult oRX or oVX alone or replacement of testosterone or estrogen did not alter CFC. Consistent with our hypothesis, we provide initial evidence that gonadal hormones at early periods of development exert a vital role in the organization and development of CFC in male and female rats.
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1371/journal.pone.0282293
الاتاحة: http://dx.doi.org/10.1371/journal.pone.0282293
https://dx.plos.org/10.1371/journal.pone.0282293
Rights: http://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.DEE60BF8
قاعدة البيانات: BASE
الوصف
DOI:10.1371/journal.pone.0282293