Academic Journal
Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database
| العنوان: | Regulators of G protein Signaling (RGS) proteins (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database |
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| المؤلفون: | Ahlers-Dannen, Katelin E., Alqinyah, Mohammed, Bodle, Christopher, Bou Dagher, Josephine, Chakravarti, Bandana, Choudhuri, Shreoshi P., Druey, Kirk M., Fisher, Rory A., Gerber, Kyle J., Hepler, John R., Hooks, Shelley B., Kantheti, Havish S., Karaj, Behirda, Lee, Jae-Kyung, Luo, Zili, Martemyanov, Kirill, Mascarenhas, Luke D., Phan Thi Nhu, Hoa, Roman, David L., Shaw, Vincent, Sjögren, Benita, Spicer, Mackenzie M., Squires, Katherine E., Sutton, Laurie, Wilkie, Thomas M., Xie, Keqiang, Zolghadri, Yalda |
| المصدر: | IUPHAR/BPS Guide to Pharmacology CITE; Vol 2020 No 4 (2020) ; 2633-1020 |
| بيانات النشر: | University of Edinburgh |
| سنة النشر: | 2020 |
| الوصف: | Regulator of G protein Signaling, or RGS, proteins serve an important regulatory role in signaling mediated by G protein-coupled receptors (GPCRs). They all share a common RGS domain that directly interacts with active, GTP-bound Gα subunits of heterotrimeric G proteins. RGS proteins stabilize the transition state for GTP hydrolysis on Gα and thus induce a conformational change in the Gα subunit that accelerates GTP hydrolysis, thereby effectively turning off signaling cascades mediated by GPCRs. This GTPase accelerating protein (GAP) activity is the canonical mechanism of action for RGS proteins, although many also possess additional functions and domains. RGS proteins are divided into four families, R4, R7, R12 and RZ based on sequence homology, domain structure as well as specificity towards Gα subunits. For reviews on RGS proteins and their potential as therapeutic targets, see e.g. [160, 377, 411, 415, 416, 512, 519, 312, 6]. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/html |
| اللغة: | English |
| Relation: | http://journals.ed.ac.uk/gtopdb-cite/article/view/5061/7172; http://journals.ed.ac.uk/gtopdb-cite/article/view/5061/7173; http://journals.ed.ac.uk/gtopdb-cite/article/view/5061/7174; http://journals.ed.ac.uk/gtopdb-cite/article/view/5061 |
| DOI: | 10.2218/gtopdb/F891/2020.4 |
| الاتاحة: | http://journals.ed.ac.uk/gtopdb-cite/article/view/5061 https://doi.org/10.2218/gtopdb/F891/2020.4 |
| Rights: | Copyright (c) 2020 The authors ; http://creativecommons.org/licenses/by-sa/4.0 |
| رقم الانضمام: | edsbas.DECA40BE |
| قاعدة البيانات: | BASE |
| DOI: | 10.2218/gtopdb/F891/2020.4 |
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