Academic Journal
The effect of hormone replacement therapy on cognition and mood
| العنوان: | The effect of hormone replacement therapy on cognition and mood |
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| المؤلفون: | Sharma, A, Davies, R, Kapoor, A, Islam, H, Webber, L, Jayasena, CNN |
| المصدر: | 295 ; 285 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Endocrinology & Metabolism, cognition, hormone replacement therapy, menopause, mood, oestrogen therapy, women, ESTROGEN PLUS PROGESTIN, QUALITY-OF-LIFE, HEALTH INITIATIVE MEMORY, TRANSDERMAL ESTRADIOL THERAPY, CONJUGATED EQUINE ESTROGENS, SHORT-TERM-MEMORY, POSTMENOPAUSAL WOMEN, DOUBLE-BLIND, DEPRESSIVE SYMPTOMS, HOT FLASHES, Humans, Female, Estrogen Replacement Therapy, Postmenopause |
| الوصف: | Objectives To summarise the available data regarding the effect of hormone replacement therapy (HRT) on cognition and mood in women. Background Complaints of impaired cognition and mood are common in the peri-menopausal and menopausal period. There is debate as to whether HRT can ameliorate this phenomenon. Design A literature search of studies using electronic databases was conducted. Both randomised control trials and observational studies were included. Patients Perimenopausal and menopausal women. Results Due to the heterogenicity of results it is challenging to draw firm conclusions. The preparations used in many of the studies are older regimes no longer routinely used clinically. The notion of a ‘critical window’ for HRT is compelling, suggesting HRT has a positive impact on cognition when administered in the peri-menopausal or early postmenopausal period but may have negative effects on cognition in the older, postmenopausal woman. The evidence would seem to suggest importance of hormonal replacement in woman undergoing a surgical menopause, especially when young. It remains unclear for how long they ought to continue HRT though until at least the natural age of the menopause seems reasonable. Evidence for a positive effect of HRT on mood is more convincing, though possibly more efficacious in the younger age group. The effect of HRT on anxiety is less clear. Conclusions Further study, particularly focusing on the more contemporaneous HRT preparations, is warranted before evidence-based conclusions can be drawn. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0300-0664 |
| Relation: | Clinical Endocrinology; http://hdl.handle.net/10044/1/103921 |
| DOI: | 10.1111/cen.14856 |
| الاتاحة: | http://hdl.handle.net/10044/1/103921 https://doi.org/10.1111/cen.14856 |
| Rights: | © 2022 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. ; http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.DEAD8EBE |
| قاعدة البيانات: | BASE |
| تدمد: | 03000664 |
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| DOI: | 10.1111/cen.14856 |