Academic Journal
OP0286 CHARACTERISTICS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE (COVID-19 GRA)
| العنوان: | OP0286 CHARACTERISTICS ASSOCIATED WITH SEVERE COVID-19 OUTCOMES IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): RESULTS FROM THE COVID-19 GLOBAL RHEUMATOLOGY ALLIANCE (COVID-19 GRA) |
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| المؤلفون: | Ugarte-Gil, M. F., Alarcon, G. S., Seet, A., Izadi, Z., Reategui Sokolova, C., Clarke, A. E., Wise, L., Pons-Estel, G., Santos, M. J., Bernatsky, S., Mathias, L., Lim, N., Sparks, J., Wallace, Z., Hyrich, K., Strangfeld, A., Gossec, L., Carmona, L., Mateus, E., Lawson-Tovey, S., Trupin, L., Rush, S., Schmajuk, G., Katz, P., Jacobsohn, L., Al Emadi, S., Gilbert, E., Duarte-Garcia, A., Valenzuela-Almada, M., Hsu, T., D’silva, K., Serling-Boyd, N., Dieudé, P., Nikiphorou, E., Kronzer, V., Singh, N., Wallace, B., Akpabio, A., Thomas, R., Bhana, S., Costello, W., Grainger, R., Hausmann, J., Liew, J., Sirotich, E., Sufka, P., Robinson, P., Machado, P., Gianfrancesco, M., Yazdany, J. |
| المصدر: | Annals of the Rheumatic Diseases ; volume 80, issue Suppl 1, page 173.2-175 ; ISSN 0003-4967 1468-2060 |
| بيانات النشر: | BMJ |
| سنة النشر: | 2021 |
| الوصف: | Background: An increased risk of severe COVID-19 outcomes may be seen in patients with autoimmune diseases on moderate to high daily doses of glucocorticoids, as well as in those with comorbidities. However, specific information about COVID-19 outcomes in SLE is scarce. Objectives: To determine the characteristics associated with severe COVID-19 outcomes in a multi-national cross-sectional registry of COVID-19 patients with SLE. Methods: SLE adult patients from a physician-reported registry of the COVID-19 GRA were studied. Variables collected at COVID-19 diagnosis included age, sex, race/ethnicity, region, comorbidities, disease activity, time period of COVID-19 diagnosis, glucocorticoid (GC) dose, and immunomodulatory therapy. Immunomodulatory therapy was categorized as: antimalarials only, no SLE therapy, traditional immunosuppressive (IS) drug monotherapy, biologics/targeted synthetic IS drug monotherapy, and biologic and traditional IS drug combination therapy. We used an ordinal COVID-19 severity outcome defined as: not hospitalized/hospitalized without supplementary oxygen; hospitalized with non-invasive ventilation; hospitalized with mechanical ventilation/extracorporeal membrane oxygenation; and death. An ordinal logistic regression model was constructed to assess the association between demographic characteristics, comorbidities, medications, disease activity and COVID-19 severity. This assumed that the relationship between each pair of outcome groups is of the same direction and magnitude. Results: Of 1069 SLE patients included, 1047 (89.6%) were female, with a mean age of 44.5 (SD: 14.1) years. Patient outcomes included 815 (78.8%) not hospitalized/hospitalized without supplementary oxygen; 116 (11.2) hospitalized with non-invasive ventilation, 25 (2.4%) hospitalized with mechanical ventilation/extracorporeal membrane oxygenation and 78 (7.5%) died. In a multivariate model (n=804), increased age [OR=1.03 (1.01, 1.04)], male sex [OR =1.93 (1.21, 3.08)], COVID-19 diagnosis between June 2020 and January ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1136/annrheumdis-2021-eular.2984 |
| الاتاحة: | http://dx.doi.org/10.1136/annrheumdis-2021-eular.2984 https://syndication.highwire.org/content/doi/10.1136/annrheumdis-2021-eular.2984 |
| رقم الانضمام: | edsbas.DE846526 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/annrheumdis-2021-eular.2984 |
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