Academic Journal
Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion
| العنوان: | Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion |
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| المؤلفون: | Tuz, Ali A., Ghosh, Susmita, Karsch, Laura, Ttoouli, Dimitris, Sata, Sai P., Ulusoy, Özgür, Kraus, Andreas, Hoerenbaum, Nils, Wolf, Jan-Niklas, Lohmann, Sabrina, Zwirnlein, Franziska, Kaygusuz, Viola, Lakovic, Vivian, Tummes, Hannah-Lea, Beer, Alexander, Gallert, Markus, Thiebes, Stephanie, Qefalia, Altea, Cibir, Zülal, Antler, Medina, Korste, Sebastian, Haj Yehia, Elias, Michel, Lars, Rassaf, Tienush, Kaltwasser, Britta, Abdelrahman, Hossam, Mohamud Yusuf, Ayan, Wang, Chen, Yin, Dongpei, Haeusler, Lars, Lueong, Smiths, Richter, Mathis, Engel, Daniel R., Stenzel, Martin, Soehnlein, Oliver, Frank, Benedikt, Solo-Nomenjanahary, Mialitiana, Ho-Tin-Noé, Benoît, Siveke, Jens T., Totzeck, Matthias, Hoffmann, Daniel, Grüneboom, Anika, Hagemann, Nina, Hasenberg, Anja, Desilles, Jean-Philippe, Mazighi, Mikael, Sickmann, Albert, Chen, Jianxu, Hermann, Dirk M., Gunzer, Matthias |
| المساهمون: | Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie, Collaborative Research Centers |
| المصدر: | Nature Cardiovascular Research ; volume 3, issue 5, page 525-540 ; ISSN 2731-0590 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer’s patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3–10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA + cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s44161-024-00462-8 |
| الاتاحة: | http://dx.doi.org/10.1038/s44161-024-00462-8 https://www.nature.com/articles/s44161-024-00462-8.pdf https://www.nature.com/articles/s44161-024-00462-8 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.DE621618 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s44161-024-00462-8 |
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