التفاصيل البيبلوغرافية
| العنوان: |
Electronic monitoring of potential adverse drug events related to lopinavir/ritonavir and hydroxychloroquine during the first wave of COVID-19 |
| المؤلفون: |
Skalafouris, Christian, Samer, Caroline Flora, Stirnemann, Jérôme, Grosgurin, Olivier, Eggimann, François, Grauser, Damien, Reny, Jean-Luc, Bonnabry, Pascal, Guignard, Bertrand |
| المصدر: |
ISSN: 2047-9956 ; European journal of hospital pharmacy, (2021. |
| سنة النشر: |
2021 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/615, info:eu-repo/classification/ddc/616, info:eu-repo/classification/ddc/617, COVID-19, Automation, Drug-related side effects and adverse reactions, Hospital, Medical informatics, Pharmacy service |
| الوصف: |
During Switzerland's first wave of COVID-19, clinical pharmacy activities during medical rounds in Geneva University Hospitals were replaced by targeted remote interventions. We describe using the electronic PharmaCheck system to screen high-risk situations of adverse drug events (ADEs), particularly targeting prescriptions of lopinavir/ritonavir (LPVr) and hydroxychloroquine (HCQ) in the presence of contraindications or prescriptions outside institutional guidelines. Of 416 patients receiving LPVr and/or HCQ, 182 alerts were triggered for 164 (39.4%) patients. The main associated risk factors of ADEs were drug-drug interactions, QTc interval prolongation, electrolyte disorder and inadequate LPVr dosage. Therapeutic optimisation recommended by a pharmacist or proposals for additional monitoring were accepted in 80% (n=36) of cases. Combined with pharmacist contextualisation to the clinical context, PharmaCheck made it possible to successfully adapt clinical pharmacist activities by switching from a global to a targeted analysis mode in an emergency context. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/33832918; https://archive-ouverte.unige.ch/unige:160707; unige:160707 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:160707 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsbas.DE4B531F |
| قاعدة البيانات: |
BASE |