Academic Journal
Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency:Findings from the SarcoPhAge Cohort
| العنوان: | Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency:Findings from the SarcoPhAge Cohort |
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| المؤلفون: | Ladang, Aurélie, Gendebien, Anne Sophie, Kovacs, Stéphanie, Demonceau, Céline, Beaudart, Charlotte, Peeters, Stéphanie, Alokail, Majed S., Al-Daghri, Nasser M., Le Goff, Caroline, Reginster, Jean Yves, Bruyere, Olivier, Cavalier, Etienne |
| المصدر: | Ladang , A , Gendebien , A S , Kovacs , S , Demonceau , C , Beaudart , C , Peeters , S , Alokail , M S , Al-Daghri , N M , Le Goff , C , Reginster , J Y , Bruyere , O & Cavalier , E 2024 , ' Investigation of the Vitamin D Metabolite Ratio (VMR) as a Marker of Functional Vitamin D Deficiency : Findings from the SarcoPhAge Cohort ' , Nutrients , vol. 16 , no. 19 , 3224 . https://doi.org/10.3390/nu16193224 |
| سنة النشر: | 2024 |
| المجموعة: | Research Portal - University of Namur / Portail de la recherche de l'Université de Namur |
| مصطلحات موضوعية: | functional vitamin D deficiency, mortality prediction, parathyroid hormone (PTH), vitamin D metabolite ratio (VMR) |
| الوصف: | Background: The vitamin D metabolite ratio (VMR) has recently been identified as a potentially better indicator of vitamin D deficiency than 25-hydroxyvitamin D (25(OH)D) alone. This study aims to validate these findings by demonstrating that VMR is more strongly correlated with parathyroid hormone (PTH) levels than 25(OH)D and 24,25-dihydroxyvitamin D (24,25(OH) 2 D). In addition, the study investigates VMR as a more effective predictor of mortality than 25(OH)D and 24,25(OH) 2 D. Methods: The SarcoPhAge cohort is a Belgian cohort of community-dwelling older adults. Levels of 25(OH)D and 24,25(OH) 2 D were measured in 204 serum samples collected at the second year of follow-up using liquid chromatography–tandem mass spectrometry (LC–MS/MS), and VMR was calculated using the formula: VMR = (24,25(OH)D/25(OH)D) × 100. Vitamin D deficiency cut-offs were defined at 25(OH)D < 20 ng/mL, 24,25(OH) 2 D < 1.2 ng/mL, or VMR < 4% according to previously proposed cut-offs. Participants were followed for up to 9 years. Results: A total of 35 individuals (17.2%) had 25(OH)D < 20 ng/mL, 40 individuals (19.6%) had 24,25(OH) 2 D < 1.2 ng/mL, and 14 individuals (7.0%) had VMR < 4%. All three markers, 25(OH)D, 24,25(OH) 2 D, and VMR, were independently associated with PTH levels, with VMR showing the strongest correlation (rho: −0.292; p < 0.0001). When categorized into quartiles, only 24,25(OH)2D and VMR showed significant increases in PTH levels across quartiles (p = 0.002 and p < 0.0001, respectively). When cut-offs for low vitamin D status were applied, patients with low VMR had the highest rate of all-cause mortality. However, in a Cox proportional hazard regression model, both low VMR profile and low 25(OH)D profile were risk factors for all-cause mortality. Conclusions: This study confirms that VMR is an efficient biomarker for assessing functional vitamin D deficiency. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.3390/nu16193224 |
| الاتاحة: | https://researchportal.unamur.be/en/publications/fdd1692d-ba04-4bef-895d-2fde3d43ddd8 https://doi.org/10.3390/nu16193224 http://www.scopus.com/inward/record.url?scp=85206533694&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DE3F736E |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nu16193224 |
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