Academic Journal
Activation of intestinal spinal afferent endings by changes in intra‐mesenteric arterial pressure
| العنوان: | Activation of intestinal spinal afferent endings by changes in intra‐mesenteric arterial pressure |
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| المؤلفون: | Humenick, A, Chen, B N, Wiklendt, Lukasz, Spencer, Nicholas John, Zagorodnyuk, Vladimir Petrovich, Dinning, Phillip, Costa, Marcello, Brookes, Simon Jonathan |
| بيانات النشر: | John Wiley & Sons, inc. |
| سنة النشر: | 2015 |
| المجموعة: | Flinders University, Adelaide: Flinders Academic Commons (FAC) |
| الوصف: | Author manuscript made available following 12 month embargo from date of publication (25 June 2015) in accordance with publisher copyright policy. ; KEY POINTS: A major class of mechano-nociceptors to the intestine have mechanotransduction sites on extramural and intramural arteries and arterioles ('vascular afferents'). These sensory neurons can be activated by compression or axial stretch of vessels. Using isolated preparations we showed that increasing intra-arterial pressure, within the physiological range, activated mechano-nociceptors on vessels in intact mesenteric arcades, but not in isolated arteries. This suggests that distortion of the branching vascular tree is the mechanical adequate stimulus for these sensory neurons, rather than simple distension. The same rises in pressure also activated intestinal peristalsis in a partially capsaicin-sensitive manner indicating that pressure-sensitive vascular afferents influence enteric circuits. The results identify the mechanical adequate stimulus for a major class of mechano-nociceptors with endings on blood vessels supplying the gut wall; these afferents have similar endings to ones supplying other viscera, striated muscle and dural vessels. ABSTRACT: Spinal sensory neurons innervate many large blood vessels throughout the body. Their activation causes the hallmarks of neurogenic inflammation: vasodilatation through the release of the neuropeptide calcitonin gene-related peptide and plasma extravasation via tachykinins. The same vasodilator afferent neurons show mechanical sensitivity, responding to crushing, compression or axial stretch of blood vessels - responses which activate pain pathways and which can be modified by cell damage and inflammation. In the present study, we tested whether spinal afferent axons ending on branching mesenteric arteries ('vascular afferents') are sensitive to increased intravascular pressure. From a holding pressure of 5 mmHg, distension to 20, 40, 60 or 80 mmHg caused graded, slowly adapting increases in firing of vascular ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0022-3751 |
| Relation: | http://purl.org/au-research/grants/NHMRC/1048195; NHMRC/1048195; Humenick A, Chen BN, Wiklendt L, Spencer NJ, Zagorodnyuk VP, Dinnin PG, Costa M, Brookes SJ (2015). Activation of intestinal spinal afferents endings by changes in intra-mesenteric arterial pressure. Journal of Physiology. 593: 3693-3709.; http://hdl.handle.net/2328/35973; https://doi.org/10.1113/JP270378 |
| DOI: | 10.1113/JP270378 |
| الاتاحة: | http://hdl.handle.net/2328/35973 https://doi.org/10.1113/JP270378 |
| Rights: | Copyright © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society. ; The Authors ; In Copyright |
| رقم الانضمام: | edsbas.DE2B5684 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00223751 |
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| DOI: | 10.1113/JP270378 |