Academic Journal
Preoperative Predictors of Neoplasia in Patients Undergoing Small Bowel Resection for Complicated Crohn's Disease: A Multicentre Case-Control Study.
| العنوان: | Preoperative Predictors of Neoplasia in Patients Undergoing Small Bowel Resection for Complicated Crohn's Disease: A Multicentre Case-Control Study. |
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| المؤلفون: | Chappe, Capucine, Salut, Cecile, Amiot, Aurelien, Gaye, Delphine, Frulio, Nora, Lapuyade, Bruno, Vuitton, Lucine, Altwegg, Romain, Gilletta, Cyrielle, Fumery, Mathurin, Bouguen, Guillaume, Serrero, Melanie, Nachury, Maria, de Suray, Nicolas, Caillo, Ludovic, Simon, Mireille, Laharie, David, Rivière, Pauline, Poullenot, Florian |
| المساهمون: | Université de Bordeaux (UB), Hôpital Saint-André Bordeaux, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Haut-Lévêque CHU Bordeaux, Centre Hospitalier Universitaire de Bordeaux (CHU Bordeaux), Service de Gastro-Entérologie CHRU Besançon, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital Saint Eloi CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou, Centre d'Investigation Clinique Rennes (CIC), Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Nord CHU - APHM, Institute for Translational Research in Inflammation - U 1286 (INFINITE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de Cancérologie de Lorraine - Alexis Vautrin Nancy (UNICANCER/ICL), UNICANCER |
| المصدر: | ISSN: 2072-6694. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | Crohn’s disease, predictive factors, small bowel adenocarcinoma, small bowel neoplasia, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Crohn's disease (CD) is associated with an increased risk of small bowel neoplasia (SBN). We aimed to assess preoperative predictors of SBN in CD patients. We conducted a retrospective case-control study including CD patients who underwent surgery: cases were diagnosed with SBN on histopathological analysis and controls had no neoplasia. Preoperative cross-sectional imaging was reviewed by a panel of blinded expert radiologists. Fifty cases were matched to one hundred and fifty consecutive controls. In multivariable analysis, predictors of SBN were age ≥ 50 years (OR = 28, 95% CI = 5.05-206), median CD duration ≥ 17.5 years (OR = 4.25, 95% CI = 1.33-14.3), and surgery for stricture (OR = 5.84, 95% CI = 1.27-35.4). The predictors of small bowel adenocarcinoma were age ≥ 50 years (OR = 5.14, 95% CI = 2.12-12.7), CD duration ≥ 15 years (OR = 5.65, 95% CI = 2.33-14.3), and digestive wall thickening > 8 mm (OR = 3.79, 95% CI = 1.45-11.3). A predictive score based on the aforementioned factors was constructed. Almost 73.7% of patients with a high score had SBA. Old age, long small bowel CD duration, and stricture predicted the presence of SBN, particularly adenocarcinoma when patients have digestive wall thickening > 8 mm on preoperative imaging. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37046666; PUBMED: 37046666; PUBMEDCENTRAL: PMC10093720 |
| DOI: | 10.3390/cancers15072004 |
| الاتاحة: | https://u-picardie.hal.science/hal-04076226 https://u-picardie.hal.science/hal-04076226v1/document https://u-picardie.hal.science/hal-04076226v1/file/cancers-15-02004.pdf https://doi.org/10.3390/cancers15072004 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.DDFEDCD5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers15072004 |
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