Academic Journal
Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice
| العنوان: | Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice |
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| المؤلفون: | Hermier, Dominique, Lan, Annaig, Tellier, Fredeŕique, Blais, Anne, Culetto, Marta, Mathe, Veŕonique, Bellec, Yannick, Gissot, Lionel, Schmidely, Philippe, Faure, Jean-Denis |
| المساهمون: | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Jean-Pierre Bourgin (IJPB), Modélisation Systémique Appliquée aux Ruminants (MoSAR), ANR-10-LABX-0040,SPS,Saclay Plant Sciences(2010), ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011) |
| المصدر: | ISSN: 0021-8561. |
| بيانات النشر: | CCSD American Chemical Society |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | digestibility, sphingolipid, Camelina sativa, metabolic syndrome, acyl chain, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.BV.AP]Life Sciences [q-bio]/Vegetal Biology/Plant breeding, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics |
| الوصف: | International audience ; Sphingolipids appear as a promising class of components susceptible to prevent the onset of the metabolic syndrome (MetS). Gut availability and effects of Camelina sativa sphingolipids were investigated in a mouse model of dietary-induced MetS. Seed meals from two Camelina sativa lines enriched, respectively, in C24-and C16-NH 2 − glycosyl-inositol-phosphoryl-ceramides (NH 2 GIPC) were used in hypercaloric diets. After 5 weeks on these two hypercaloric diets, two markers of the MetS were alleviated (adiposity and insulin resistance) as well as inflammation markers and colon barrier dysfunction. A more pronounced effect was observed with the C16-NH 2 GIPC-enriched HC diet, in particular for colon barrier function. Despite a lower digestibility, C16-NH 2 GIPC were more prevalent in the intestine wall. Sphingolipids provided as camelina meal can therefore counteract some deleterious effects of a hypercaloric diet in mice at the intestinal and systemic levels. Interestingly, these beneficial effects seem partly dependent on sphingolipid acyl chain length. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31852192; PRODINRA: 492959; PUBMED: 31852192; WOS: 000509427900011 |
| DOI: | 10.1021/acs.jafc.9b06829 |
| الاتاحة: | https://agroparistech.hal.science/hal-02463037 https://agroparistech.hal.science/hal-02463037v1/document https://agroparistech.hal.science/hal-02463037v1/file/Revised%20Manuscript%2012-2019_jd.pdf https://doi.org/10.1021/acs.jafc.9b06829 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.DDF7C2CC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jafc.9b06829 |
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