Academic Journal
Cranial Morphology Associated With Syndromic Craniosynostosis: A Potential Detection of Abnormality in Patient's Cranial Growth Using Angular Statistics
| العنوان: | Cranial Morphology Associated With Syndromic Craniosynostosis: A Potential Detection of Abnormality in Patient's Cranial Growth Using Angular Statistics |
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| المؤلفون: | Zulkipli, Nur Syahirah, Satari, Siti Zanariah, Hariri, Firdaus, Abdullah, Norli Anida, Wan Yusoff, Wan Nur Syahidah, Hussin, Abdul Ghapor |
| المساهمون: | Ministry of Higher Education, Malaysia, Universiti Malaysia Pahang |
| المصدر: | The Cleft Palate Craniofacial Journal ; volume 60, issue 11, page 1484-1493 ; ISSN 1055-6656 1545-1569 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2022 |
| الوصف: | Introduction Apert, Crouzon, and Pfeiffer syndromes are common genetic syndromes related to syndromic craniosynostosis (SC), whereby it is a congenital defect that occurs when the cranial growth is distorted. Identifying cranial angles associated with these 3 syndromes may assist the surgical team to focus on a specific cranial part during the intervention planning, thus optimizing surgical outcomes and reducing potential morbidity. Objective The aim of this study is to identify the cranial angles, which are associated with Apert, Crouzon, and Pfeiffer syndromes. Methods The cranial computed tomography scan images of 17 patients with SC and 22 control groups aged 0 to 12 years who were treated in the University Malaya Medical Centre were obtained, while 12 angular measurements were attained using the Mimics software. The angular data were then divided into 2 groups (patients aged 0 to 24 months and >24 months). This work proposes a 95% confidence interval (CI) for angular mean to detect the abnormality in patient's cranial growth for the SC syndromes. Results The 95% CI of angular mean for the control group was calculated and used as an indicator to confirm the abnormality in patient's cranial growth that is associated with the 3 syndromes. The results showed that there are different cranial angles associated with these 3 syndromes. Conclusions All cranial angles of the patients with these syndromes lie outside the 95% CI of angular mean of control group, indicating the reliability of the proposed CI in the identification of abnormality in the patient's cranial growth. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/10556656221107524 |
| الاتاحة: | https://doi.org/10.1177/10556656221107524 https://journals.sagepub.com/doi/pdf/10.1177/10556656221107524 https://journals.sagepub.com/doi/full-xml/10.1177/10556656221107524 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.DDDE69C7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/10556656221107524 |
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