Conference
Revisiting the Role of Esophageal Mucosal Dilated Intercellular Spaces in the Diagnosis and Pathophysiology of Heartburn
| العنوان: | Revisiting the Role of Esophageal Mucosal Dilated Intercellular Spaces in the Diagnosis and Pathophysiology of Heartburn |
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| المؤلفون: | Ergun, P., Gorgulu, V., Kipcak, S., Doganavsargil, B., Sifrim, D., Bor, S. |
| بيانات النشر: | Korean Society of Neurogastroenterology and Motility |
| سنة النشر: | 2023 |
| المجموعة: | Ege University Institutional Repository |
| مصطلحات موضوعية: | Endoscopy, gastrointestinal, Electric impedance, Extracellular space, Gastroesophageal reflux, Heartburn, adult, area under the curve, Conference Paper, controlled study, diagnostic test accuracy study, esophagus mucosa, female, human, impedance, intercellular space, major clinical study, male, non erosive reflux disease, pathophysiology, predictive value, reflux esophagitis, sensitivity and specificity |
| الوصف: | Dilated intercellular spaces (DISs) facilitate the diffusion of noxious agents into the deep layers of the esophageal epithelium. The role of DIS in heartburn pathogenesis is still controversial. Therefore, we aim to reinvestigate DIS in an extensively evaluated group of patients and healthy controls (HCs). Methods We classified 149 subjects into the following groups: 15 HC, 58 mild erosive reflux disease (ERD), 17 severe ERD, 25 nonerosive reflux disease (NERD), 15 reflux hypersensitivity (RH), and 19 functional heartburn (FH). A total of 100 length measurements were performed for each patient’s biopsy. Results The overall intercellular spaces (ISs) value of gastroesophageal reflux disease (GERD) patients was higher than that of HC (P = 0.020). In phenotypes, mild ERD (vs HC [P = 0.036], NERD [P = 0.004], RH [P = 0.014]) and severe ERD (vs HC [P = 0.002], NERD [P 0.001], RH [P = 0.001], FH [P = 0.004]) showed significantly higher IS. There was no significant difference between the HC, NERD, RH, and FH groups. The 1.12 μm DIS cutoff value had 63.5% sensitivity and 66.7% specificity in the diagnosis of GERD. There was a weak correlation (r = 0.302) between the IS value and acid exposure time, and a weak correlation (r = −0.359) between the IS value and baseline impedance. A strong correlation was shown between acid exposure time and baseline impedance (r = −0.783). Conclusions Since the IS length measurement had better discrimination power only in erosive groups, it is not feasible to use in daily routine to discriminate other nonerosive phenotypes and FH. The role of DIS in heartburn in nonerosive patients should be reconsidered. © 2023 The Korean Society of Neurogastroenterology and Motility. ; OP206, SS-011; Ege Üniversitesi: TGA-2021-22732; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 118S260 |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| تدمد: | 2093-0879 |
| Relation: | Journal of Neurogastroenterology and Motility; Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı; https://hdl.handle.net/11454/92852; https://doi.org/10.5056/jnm22142; 29; 436; 445 |
| DOI: | 10.5056/jnm22142 |
| الاتاحة: | https://hdl.handle.net/11454/92852 https://doi.org/10.5056/jnm22142 |
| Rights: | open |
| رقم الانضمام: | edsbas.DDDADFB2 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20930879 |
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| DOI: | 10.5056/jnm22142 |