Academic Journal
Gut Microbiota Ecological and Functional Modulation in Post-Stroke Recovery Patients:An Italian Study
| العنوان: | Gut Microbiota Ecological and Functional Modulation in Post-Stroke Recovery Patients:An Italian Study |
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| المؤلفون: | Marsiglia, Riccardo, Marangelo, Chiara, Vernocchi, Pamela, Scanu, Matteo, Pane, Stefania, Russo, Alessandra, Guanziroli, Eleonora, Del Chierico, Federica, Valeriani, Massimiliano, Molteni, Franco, Putignani, Lorenza |
| المصدر: | Marsiglia , R , Marangelo , C , Vernocchi , P , Scanu , M , Pane , S , Russo , A , Guanziroli , E , Del Chierico , F , Valeriani , M , Molteni , F & Putignani , L 2024 , ' Gut Microbiota Ecological and Functional Modulation in Post-Stroke Recovery Patients : An Italian Study ' , Microorganisms , vol. 12 , no. 1 , 37 . https://doi.org/10.3390/microorganisms12010037 |
| سنة النشر: | 2024 |
| المجموعة: | Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| مصطلحات موضوعية: | SCFAs, fecal zonulin, gut microbiota ecology, gut–brain axis, ischemic stroke, tryptophan derivatives |
| الوصف: | Ischemic stroke (IS) can be caused by perturbations of the gut-brain axis. An imbalance in the gut microbiota (GM), or dysbiosis, may be linked to several IS risk factors and can influence the brain through the production of different metabolites, such as short-chain fatty acids (SCFAs), indole and derivatives. This study examines ecological changes in the GM and its metabolic activities after stroke. Fecal samples of 10 IS patients were compared to 21 healthy controls (CTRLs). GM ecological profiles were generated via 16S rRNA taxonomy as functional profiles using metabolomics analysis performed with a gas chromatograph coupled to a mass spectrometer (GC-MS). Additionally fecal zonulin, a marker of gut permeability, was measured using an enzyme-linked immuno assay (ELISA). Data were analyzed using univariate and multivariate statistical analyses and correlated with clinical features and biochemical variables using correlation and nonparametric tests. Metabolomic analyses, carried out on a subject subgroup, revealed a high concentration of fecal metabolites, such as SCFAs, in the GM of IS patients, which was corroborated by the enrichment of SCFA-producing bacterial genera such as Bacteroides, Christensellaceae, Alistipes and Akkermansia. Conversely, indole and 3-methyl indole (skatole) decreased compared to a subset of six CTRLs. This study illustrates how IS might affect the gut microbial milieu and may suggest potential microbial and metabolic biomarkers of IS. Expanded populations of Akkermansia and enrichment of acetic acid could be considered potential disease phenotype signatures. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3390/microorganisms12010037 |
| الاتاحة: | https://vbn.aau.dk/da/publications/47b7573b-e9bb-40c0-ad13-19c0ad811381 https://doi.org/10.3390/microorganisms12010037 https://vbn.aau.dk/ws/files/644663632/microorganisms-12-00037.pdf http://www.scopus.com/inward/record.url?scp=85183181400&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DDB52675 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms12010037 |
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