Conference
Evaluation and comparison of the effects of artesunate, dexamethasone, and tacrolimus on sciatic nerve regeneration
| العنوان: | Evaluation and comparison of the effects of artesunate, dexamethasone, and tacrolimus on sciatic nerve regeneration |
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| المؤلفون: | Uzun, Tuğçenur, Toptaş, Orçun, Saylan, Aslıhan, Carver, Hande, Türkoğlu, Şule Aydın |
| المساهمون: | BAİBÜ, Diş Hekimliği Fakültesi, Ağız Diş ve Çene Cerrahisi Ana Bilim Dalı, orcid:0000-0002-0062-4054, orcid:0000-0002-5099-5128, orcid:0000-0002-1065-3254, orcid:0000-0001-9613-5564, orcid:0000-0001-8616-832X, Uzun, Tuğçenur, Toptaş, Orçun, Saylan, Aslıhan, Carver, Hande, Türkoğlu, Şule Aydın |
| بيانات النشر: | W B Saunders Co-Elsevier Inc |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Sciatic Nerve, Electromyographic (EMG) Measurement |
| الوصف: | Joint Congress of the International-Association-of-Oral-and-Maxillofacial-Surgeons and the Oral-and-Maxillofacial-Surgery-Society-of-Turkey -- MAY 09-13, 2018 -- Antalya, TURKEY ; WOS:000466147700045 ; PubMed: 30689960 ; Purpose: To examine the effect of topical artesunate treatment on peripheral nerve regeneration and compare it with the effects of topical tacrolimus and dexamethasone on nerve regeneration. Materials and Methods: Thirty-two Wistar albino rats were used in this study. The rats were divided into 6 groups: sham, saline, petrolatum, artesunate, tacrolimus, and dexamethasone. A compression injury was generated in the right sciatic nerve in all groups except the sham group. In the sham group, the nerve was dissected but compression was not applied. In the groups in which compression was applied, the agents were absorbed through resorbable gelatin sponges applied to the injured region. At the end of 4 weeks, walking analysis, electromyographic measurements, and histopathologic examinations were conducted. Results: When the sciatic function index and electrophysiologic measurements were evaluated, artesunate, tacrolimus, and dexamethasone exhibited positive effects on nerve regeneration (P <.05); there were no significant differences among these 3 agents (P >.05). Histopathologic examination showed that artesunate decreased fibrosis scores and inflammation and increased the diameter of myelinated axons; tacrolimus decreased fibroblast scores; and dexamethasone only decreased fibrosis scores (P <.05). Immunohistochemical analysis showed that the artesunate and dexamethasone groups had more positive immunoreactivity to nerve growth factor than did the saline group (P <.05). Conclusions: Topical artesunate treatment had a positive effect on peripheral nerve regeneration. There were no relevant differences between the topical forms of dexamethasone and tacrolimus for peripheral nerve regeneration. (C) 2018 American Association of Oral and Maxillofacial Surgeons ; Oral & Maxillofacial Surg ... |
| نوع الوثيقة: | conference object |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0278-2391 1531-5053 |
| Relation: | Konferans Öğesi - Uluslararası - Kurum Öğretim Elemanı; Journal Of Oral And Maxillofacial Surgery; https://doi.org/10.1016/j.joms.2018.12.019; https://hdl.handle.net/20.500.12491/10037; 77 |
| DOI: | 10.1016/j.joms.2018.12.019 |
| الاتاحة: | https://hdl.handle.net/20.500.12491/10037 https://doi.org/10.1016/j.joms.2018.12.019 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.DD70703B |
| قاعدة البيانات: | BASE |
| تدمد: | 02782391 15315053 |
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| DOI: | 10.1016/j.joms.2018.12.019 |