التفاصيل البيبلوغرافية
| العنوان: |
Angiogenic and lymphangiogenic profiles in histological variants of papillary thyroid carcinoma |
| المؤلفون: |
Škuletić Vesna, Radosavljević Gordana D, Pantić Jelena, Marković Simović Bojana, Jovanović Ivan, Janković Nikola, Petrović Dušica, Jevtović Andra, Džodić Radan, Arsenijević Nebojša |
| المصدر: |
Poli Arch of Inter Medi, 127(6), 429-437, (2017-04-19) |
| بيانات النشر: |
Zenodo |
| سنة النشر: |
2017 |
| المجموعة: |
Zenodo |
| مصطلحات موضوعية: |
angiogenesis, papillary thyroid carcinoma, lymphangiogenesis |
| الوصف: |
Introduction. Papillary thyroid carcinoma (PTC) is a well‑differentiated tumor that occurs in several histological variants whose biological behaviors remain unclear. Angiogenesis and lymphangiogenesis are critical processes that enable tumor progression. Objectives. The aim of this study was to evaluate the angiogenic and lymphangiogenic phenotypes of PTC, considering the differences between histological variants. Patients and methods. Angiogenic and lymphangiogenic profiles were analyzed by determining microvascular density (MVD) and lymphatic vessel density (LVD) in 73 cases of PTC, using immunohistochemistry. To assess the biological markers involved in blood and lymph vessel formation, the expression of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX‑2), and p27kip1 (p27) was determined. Results. MVD was significantly higher in patients with high‑risk PTC and in those with local extrathyroidal and vascular invasion. Positive VEGF expression was strongly associated with high MVD and age‑related tumor enlargement. The presence of lymph vessel invasion was associated with the expression of either VEGF or COX‑2. The analysis of angiogenesis and lymphangiogenesis in different histological variants of PTC revealed elevated LVD rather than MVD in the follicular variant of PTC (FV‑PTC). Lower MVD was observed in FV‑PTC relative to the classic variant of PTC (CV‑PTC). The frequency of VEGF‑positive tumors was higher in CV‑PTC than in FV‑PTC. A significant association between COX‑2 and p27 expression was observed in FV‑PTC but not in CV‑PTC. Conclusions. These results suggest that VEGF, COX‑2, and p27 may be important biological markers that determine the angiogenic and lymphangiogenic potentials of PTC, particularly between the follicular and classic variants. ; Supported by Faculty of Medicine Sciences of the University of Kragujevac, Serbia (grant JP 27/12 and MP 02/14). Authors thank to Milan Milojevic for excellent technical assistance and Snezana Cerovic and Bozidar Kovacevic, pathologists at ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
0032-3772 |
| Relation: |
https://zenodo.org/communities/iors; https://doi.org/10.20452/pamw.3999; oai:zenodo.org:3972058 |
| DOI: |
10.20452/pamw.3999 |
| الاتاحة: |
https://doi.org/10.20452/pamw.3999 |
| Rights: |
info:eu-repo/semantics/openAccess ; Creative Commons Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: |
edsbas.DD623AC |
| قاعدة البيانات: |
BASE |
Full Text Finder