Academic Journal
Fixed dosing and pharmacokinetics of S-1 in Japanese cancer patients with large body surface areas
| العنوان: | Fixed dosing and pharmacokinetics of S-1 in Japanese cancer patients with large body surface areas |
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| المؤلفون: | Fujita, K., Ichikawa, W., Yamamoto, W., Endo, H., Nagashima, F., Tanaka, R., Miya, T., Araki, K., Kodama, K., Sunakawa, Y., Narabayashi, M., Miwa, K., Ando, Y., Akiyama, Y., Kawara, K., Sasaki, Y. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2009 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | original article |
| الوصف: | Background: S-1 is an oral anticancer agent that combines tegafur (FT) with 5-chloro-2,4-dihydroxypyridine (CDHP) and potassium oxonate. The recommended initial dose of S-1 is 120 mg/day for patients with a body surface area (BSA) of ≥1.5 m2 in Japan. Methods: We examined the effects of using this fixed dose on the pharmacokinetics of FT, CDHP, and active 5-fluorouracil (5-FU) on the basis of actual BSA. The pharmacokinetics was compared between patients with a BSA of 1.5–1.75 m2 and those with a BSA of ≥1.75 m2. Results: The median areas under the time–concentration curves (AUCs) of 5-FU and CDHP were significantly lower in patients with a BSA of ≥1.75 m2 than in those with a BSA of 1.5–1.75 m2 ( P = 0.005 and 0.006, respectively; Mann–Whitney U -test). There was no difference between the groups in the median AUC of FT. Conclusion: Systemic exposure to 5-FU is significantly lower in Japanese cancer patients with a large BSA of >1.75 m2 who received the recommended fixed dose of S-1. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://annonc.oxfordjournals.org/cgi/content/short/mdn718v1; http://dx.doi.org/10.1093/annonc/mdn718 |
| DOI: | 10.1093/annonc/mdn718 |
| الاتاحة: | http://annonc.oxfordjournals.org/cgi/content/short/mdn718v1 https://doi.org/10.1093/annonc/mdn718 |
| Rights: | Copyright (C) 2009, European Society for Medical Oncology |
| رقم الانضمام: | edsbas.DD28AD88 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/annonc/mdn718 |
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