Academic Journal
Effects of non-invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta-analysis
| العنوان: | Effects of non-invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta-analysis |
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| المؤلفون: | Chen, Jian-Min, Li, Xiao-Lu, Pan, Qin-He, Yang, Ye, Xu, Sen-Ming, Xu, Jian-Wen |
| المساهمون: | National Natural Science Foundation of China, Natural Science Foundation of Guangxi Province, Guangxi Key Research and Development Program |
| المصدر: | Journal of NeuroEngineering and Rehabilitation ; volume 20, issue 1 ; ISSN 1743-0003 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Background In recent years, non-invasive brain stimulation (NIBS) has been used for motor function recovery. However, the effects of NIBS in populations with spinal cord injury (SCI) remain unclear. This study aims to conduct a meta-analysis of the existing evidence on the effects and safety of NIBS against sham groups for motor dysfunction after SCI to provide a reference for clinical decision-making. Methods Two investigators systematically screened English articles from PubMed, MEDLINE, Embase, and Cochrane Library for prospective randomized controlled trials regarding the effects of NIBS in motor function recovery after SCI. Studies with at least three sessions of NIBS were included. We assessed the methodological quality of the selected studies using the evidence-based Cochrane Collaboration’s tool. A meta-analysis was performed by pooling the standardized mean difference (SMD) with 95% confidence intervals (CI). Results A total of 14 randomized control trials involving 225 participants were included. Nine studies used repetitive transcranial magnetic stimulation (rTMS) and five studies used transcranial direct current stimulation (tDCS). The meta-analysis showed that NIBS could improve the lower extremity strength (SMD = 0.58, 95% CI = 0.02–1.14, P = 0.004), balance (SMD = 0.64, 95% CI = 0.05–1.24, P = 0.03), and decrease the spasticity (SMD = − 0.64, 95% CI = − 1.20 to − 0.03, P = 0.04). However, the motor ability of the upper extremity in the NIBS groups was not statistically significant compared with those in the control groups (upper-extremity strength: P = 0.97; function: P = 0.56; and spasticity: P = 0.12). The functional mobility in the NIBS groups did not reach statistical significance when compared with the sham NIBS groups (sham groups). Only one patient reported seizures that occurred during stimulation, and no other types of serious adverse events were reported. Conclusion NIBS appears to positively affect the motor function of the lower extremities in SCI patients, despite the ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12984-023-01129-4 |
| DOI: | 10.1186/s12984-023-01129-4.pdf |
| DOI: | 10.1186/s12984-023-01129-4/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12984-023-01129-4 https://link.springer.com/content/pdf/10.1186/s12984-023-01129-4.pdf https://link.springer.com/article/10.1186/s12984-023-01129-4/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.DD0018D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12984-023-01129-4 |
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