Academic Journal
Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity.
| العنوان: | Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity. |
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| المؤلفون: | Munckhof, I.C.L. van den, Bahrar, H., Schraa, K., Brand, T, Horst, R. ter, Graaf, M. van der, Dekker, H.M., Stienstra, R., Graaf, J. de, Joosten, L.A.B., Netea, M.G., Riksen, N.P., Rutten, J.H.W. |
| المصدر: | International Journal of Obesity and Related Metabolic Disorders, 48, 4, pp. 523-532 |
| سنة النشر: | 2024 |
| المجموعة: | Radboud University: DSpace |
| مصطلحات موضوعية: | Internal Medicine - Radboud University Medical Center, Medical Imaging - Radboud University Medical Center, Paediatrics - Radboud University Medical Center |
| الوصف: | Contains fulltext : 304753.pdf (Publisher’s version ) (Closed access) ; BACKGROUND AND AIMS: Obesity predisposes to metabolic and cardiovascular diseases. Adipose tissue inflammation and systemic inflammation contribute to these complications. There are strong sex differences in adipose tissue distribution and in systemic inflammation. Women have more subcutaneous adipose tissue (SAT) and less visceral adipose tissue (VAT) than men. We explored the sex differences in the association between the different adipose compartments and inflammatory markers that are important in cardiometabolic disease pathophysiology. METHODS: Single-center observational cohort study with 302 individuals with a BMI ≥ 27 kg/m(2). We were unable to acquire MRI data from seven individuals and from another 18 the MRI data were not usable, resulting in 277 people (155 men, 122 women), aged 55-81 years. INTERVENTION: We performed the following measurements: abdominal magnetic resonance imaging to measure VAT, and SAT (deep and superficial) volumes; circulating leukocyte counts and cytokine production capacity of peripheral blood mononuclear cells (PBMCs), circulating cytokines, adipokines, and targeted proteomics; abdominal sSAT biopsies for histology and gene expression. RESULTS: Only in women, (s)SAT volume was associated with circulating leukocytes, monocytes, and neutrophils. Circulating IL-6 and IL-18BP were associated with SAT volume in women and VAT in men. Several circulating proteins, including monocyte-colony-stimulating factor 1 and hepatocyte growth factor, are associated with sSAT in women and VAT in men. Only in women, SAT volume is associated with SAT expression of inflammatory proteins, including leptin, CD68, TNFα and IL-1α. CONCLUSION: In women living with obesity, abdominal SAT volume, especially sSAT, is associated with circulating leukocytes and inflammatory proteins. In men, these parameters mainly show associations with VAT volume. This could be because only in women, sSAT volume is associated with sSAT expression of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://hdl.handle.net/2066/304753 |
| DOI: | 10.1038/s41366-023-01444-9 |
| الاتاحة: | https://hdl.handle.net/2066/304753 https://doi.org/10.1038/s41366-023-01444-9 |
| رقم الانضمام: | edsbas.DCCF44A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41366-023-01444-9 |
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