Academic Journal
Biopolymer catalysed synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4-tetrahydropyrimidine-2-ones and evaluation of their anti-bacterial and anti-tubercular activities
| العنوان: | Biopolymer catalysed synthesis of 6-methyl-4-phenylcarbamoyl-1, 2, 3, 4-tetrahydropyrimidine-2-ones and evaluation of their anti-bacterial and anti-tubercular activities |
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| المؤلفون: | Chabukswar V., Pawar D., Handore K., Shisodia S., Diwate B., Adhav P., Jagdale S., Chabukswar A., Gaikwad V., Dallavalle S. |
| المساهمون: | V. Chabukswar, D. Pawar, K. Handore, S. Shisodia, B. Diwate, P. Adhav, S. Jagdale, A. Chabukswar, V. Gaikwad, S. Dallavalle |
| بيانات النشر: | Bentham Science Publishers |
| سنة النشر: | 2019 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Anti tubercular activity, Antibacterial activity, Biocatalysed synthesi, Carambine, Green chemistry, Solvent free, Settore CHIM/08 - Chimica Farmaceutica, Settore CHIM/06 - Chimica Organica |
| الوصف: | 1ackground: An efficient one-pot biocatalysed ultrasound assisted synthesis of dihydropyrimidinones/thiones has been developed under solvent free conditions. Materials and Methods: The use of biodegradable, non toxic, agar-powder as a catalyst provide advantages like high yield, simple operation, mild reaction condition with short reaction time. 1,2,3,4-tetrahydropyrimidine-2-ones/thiones formed were characterized by mass and 1H NMR spectroscopy. Results: The dihydropyrimidinones substituted with electron donating groups like fluorine, hydroxy along with thienyl groups exhibited good antibacterial activity. The compounds exhibited favorable binding interactions with mycobacterium target protein H37Rv. Conclusion: 4-methoxy substituted dihydropyrimidinones derivative showed significant antituberculosis activity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | volume:15; issue:4; firstpage:408; lastpage:414; numberofpages:7; journal:CURRENT BIOACTIVE COMPOUNDS; http://hdl.handle.net/2434/711083; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85070976963 |
| DOI: | 10.2174/1573407214666180503114844 |
| الاتاحة: | http://hdl.handle.net/2434/711083 https://doi.org/10.2174/1573407214666180503114844 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DCBB00A3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2174/1573407214666180503114844 |
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