Academic Journal
Biophysical Stimuli: A Review of Electrical and Mechanical Stimulation in Hyaline Cartilage
| العنوان: | Biophysical Stimuli: A Review of Electrical and Mechanical Stimulation in Hyaline Cartilage |
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| المؤلفون: | Vaca-González, Juan J., Guevara, Johana M., Moncayo, Miguel A., Castro-Abril, Hector, Hata, Yoshie, Garzón-Alvarado, Diego A. |
| المصدر: | CARTILAGE ; volume 10, issue 2, page 157-172 ; ISSN 1947-6035 1947-6043 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2017 |
| الوصف: | Objective Hyaline cartilage degenerative pathologies induce morphologic and biomechanical changes resulting in cartilage tissue damage. In pursuit of therapeutic options, electrical and mechanical stimulation have been proposed for improving tissue engineering approaches for cartilage repair. The purpose of this review was to highlight the effect of electrical stimulation and mechanical stimuli in chondrocyte behavior. Design Different information sources and the MEDLINE database were systematically revised to summarize the different contributions for the past 40 years. Results It has been shown that electric stimulation may increase cell proliferation and stimulate the synthesis of molecules associated with the extracellular matrix of the articular cartilage, such as collagen type II, aggrecan and glycosaminoglycans, while mechanical loads trigger anabolic and catabolic responses in chondrocytes. Conclusion The biophysical stimuli can increase cell proliferation and stimulate molecules associated with hyaline cartilage extracellular matrix maintenance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/1947603517730637 |
| الاتاحة: | https://doi.org/10.1177/1947603517730637 https://journals.sagepub.com/doi/pdf/10.1177/1947603517730637 https://journals.sagepub.com/doi/full-xml/10.1177/1947603517730637 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.DCA41AE9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/1947603517730637 |
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