Academic Journal
Performance of visual inspection of the cervix with acetic acid ( VIA) for triage of HPV screen‐positive women: results from the ESTAMPA study
| العنوان: | Performance of visual inspection of the cervix with acetic acid ( VIA) for triage of HPV screen‐positive women: results from the ESTAMPA study |
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| المؤلفون: | Baena, Armando, Mesher, David, Salgado, Yuli, Martínez, Sandra, Villalba, Griselda Raquel, Amarilla, Maria Luisa, Salgado, Brenda, Flores, Bettsy, Bellido‐Fuentes, Yenny, Álvarez‐Larraondo, Manuel, Valls, Joan, Lora, Oscar, Virreira‐Prout, Gonzalo, Figueroa, Jacqueline, Turcios, Elmer, Soilán, Ana María, Ortega, Marina, Celis, Marcela, González, Mauricio, Venegas, Gino, Terán, Carolina, Ferrera, Annabelle, Mendoza, Laura, Kasamatsu, Elena, Murillo, Raúl, Wiesner, Carolina, Broutet, Nathalie, Luciani, Silvana, Herrero, Rolando, Almonte, Maribel |
| المساهمون: | Centre International de Recherche sur le Cancer, National Cancer Institute, Pan American Health Organization, United Nations Development Programme |
| المصدر: | International Journal of Cancer ; volume 152, issue 8, page 1581-1592 ; ISSN 0020-7136 1097-0215 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2022 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | VIA is recommended for triage of HPV‐positive women attending cervical screening. In the multicentric ESTAMPA study, VIA performance for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) among HPV‐positive women was evaluated. Women aged 30‐64 years were screened with HPV testing and cytology and referred to colposcopy if either test was positive. At colposcopy visit, study‐trained midwives/nurses/GPs performed VIA ahead of colposcopy. VIA was considered positive if acetowhite lesions were observed in or close to the transformation zone. Ablative treatment eligibility was assessed for VIA positives. Performance indicators were estimated. Three thousand one hundred and forty‐two HPV‐positive women were included. Sensitivity for CIN3+ was 85.9% (95% CI 81.2‐89.5) among women <50 years and, although not significant, slightly lower in women 50+ (78.0%, 95% CI 65.9‐86.6). Overall specificity was 58.6% (95% CI 56.7‐60.5) and was significantly higher among women 50+ (70.3%, 95% CI 66.8‐73.5) compared to women <50 (54.3%, 95% CI 52.1‐56.5). VIA positivity was lower among women 50+ (35.2%, 95% CI 31.9‐38.6) compared to women <50 (53.2, 95% CI 51.1‐55.2). Overall eligibility for ablative treatment was 74.5% and did not differ by age. VIA sensitivity, specificity, and positivity, and ablative treatment eligibility varied highly by provider (ranges: 25%‐95.4%, 44.9%‐94.4%, 8.2%‐65.3%, 0%‐98.7%, respectively). VIA sensitivity for cervical precancer detection among HPV‐positive women performed by trained providers was high with an important reduction in referral rates. However, scaling‐up HPV screening triaged by VIA will be challenging due to the high variability of VIA performance and providers' need for training and supervision. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ijc.34384 |
| الاتاحة: | http://dx.doi.org/10.1002/ijc.34384 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ijc.34384 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ijc.34384 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.DC9AAA10 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ijc.34384 |
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