Academic Journal
JOURNAL OF MASS SPECTROMETRY J. Mass Spectrom. 35, 1237–1245 (2000) SPECIAL FEATURE: TUTORIAL Secondary ion–molecule reactions in matrix-assisted laser desorption/ionization
| العنوان: | JOURNAL OF MASS SPECTROMETRY J. Mass Spectrom. 35, 1237–1245 (2000) SPECIAL FEATURE: TUTORIAL Secondary ion–molecule reactions in matrix-assisted laser desorption/ionization |
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| المؤلفون: | R. Knochenmuss, A. Stortelder, K. Breuker, R. Zenobi |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.zenobi.ethz.ch/publications/JMassSpectrom_1237.pdf. |
| المجموعة: | CiteSeerX |
| الوصف: | Ion-molecule charge- and proton-transfer reactions in the desorption plume are considered for the case of matrix-assisted laser desorption/ionization (MALDI) with ultraviolet laser excitation, and it is proposed that they are major determinants of the observed mass spectrum. Specific MALDI phenomena which are discussed include the dominance of singly charged ions and analyte–matrix or analyte–analyte signal suppression. Should any be formed, highly charged products can be reduced by reaction with neutral matrix, yet singly charged ions cannot generally be neutralized in the same manner. Ion suppression effects can also be explained by similar reactions, which in some cases involve interconversion of dissimilar ion types. The plume is proposed often to be more under thermodynamic rather than kinetic control owing to these secondary reactions. UV/MALDI mass spectra should therefore be largely predictable, given sufficient thermodynamic information, and appropriate experimental conditions of sufficient analyte and plume density. Copyright Ó 2000 John Wiley & Sons, Ltd. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.564.8500; http://www.zenobi.ethz.ch/publications/JMassSpectrom_1237.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.564.8500 http://www.zenobi.ethz.ch/publications/JMassSpectrom_1237.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.DC9A7BAA |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |