Academic Journal
Analysis of Serological Proteins of Breast Cancer Patients Using Bioinformatics Tools
| العنوان: | Analysis of Serological Proteins of Breast Cancer Patients Using Bioinformatics Tools |
|---|---|
| المؤلفون: | Sulehri, Sabeera Afzal, Zunera Tanveer, Awan, Sumaira, Rimsha Rasheed Malik, Syed Haseeb Shah, Mariam Salim, Madiha Sana, Mariam Khaliq, Khawar Iqbal |
| المصدر: | Pak-Euro Journal of Medical and Life Sciences; Vol 3 No 4 (2020): December; 187-194 ; 2707-448X ; 2707-4471 |
| بيانات النشر: | Readers Insight Publisher |
| سنة النشر: | 2020 |
| المجموعة: | Readers Insight Publisher Journals |
| مصطلحات موضوعية: | Breast cancer, Bioinformatics tools, SDS-PAGE, Serological Proteins |
| الوصف: | The primary and most important aim of using bioinformatics tool in this study is to better understand and predict about the proteins and their 3D structure, physio chemical properties and the amino acids sequences. These information about a desired protein is important in the field of Science and Bioinformatics which made it possible for the scientists to learned about the proteins in detail and compare to experimental tools it is more accurate and explains proteins more accurately. In the world many scientists are working on these tools so they can predict different structures and functions of proteins. Breast cancer (BC) is one of the most common diseases globally affecting approximately 2.1 million women every year. Proteomics and Bioinformatics play a vital role in the better understanding of Breast cancer proteins with the help of different present bio tools. There were 70 total serum samples of positive BC patients and for the separation of proteins on the basis of their molecular weight. Bioinformatics was applied to all the detected protein’s and their sequence of amino acids. The physiochemical properties show that the detected experimental and theoretical molecular weights of Mucin-1 (MUC-1), 60 kDa heat shock protein (HSP-60), G2/mitotic-specific cyclin-B1 (Cyclin B1), Receptor tyrosine-protein kinase erbB-2 (HER-2/neu) and Myc proto-oncogene protein (C-Myc) was 115 & 119, 59 & 60, 50 & 48,52 & 48.8 and 130 & 135 KDa respectively. Putative transmembrane domains were found highly in HSP60 and Cyclin B1, less and moderately in MUC-1 and HER-2/neu and not shown in C-Myc in end result. The similarity between physio chemical properties of two or more protein can help the biologists to further work on those proteins specifically for Breast cancer diagnostics. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://readersinsight.net/PJMLS/article/view/1730/1232; https://readersinsight.net/PJMLS/article/view/1730 |
| DOI: | 10.31580/pjmls.v3i4.1730 |
| الاتاحة: | https://readersinsight.net/PJMLS/article/view/1730 https://doi.org/10.31580/pjmls.v3i4.1730 |
| Rights: | Copyright (c) 2020 Pak-Euro Journal of Medical and Life Sciences ; http://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.DC8F7901 |
| قاعدة البيانات: | BASE |
| DOI: | 10.31580/pjmls.v3i4.1730 |
|---|