Academic Journal
Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex
| العنوان: | Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex |
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| المؤلفون: | Denaxa, Myrto, Neves, Guilherme, Rabinowitz, Adam, Kemlo, Sarah, Liodis, Petros, Burrone, Juan, Pachnis, Vassilis |
| المصدر: | Denaxa , M , Neves , G , Rabinowitz , A , Kemlo , S , Liodis , P , Burrone , J & Pachnis , V 2018 , ' Modulation of Apoptosis Controls Inhibitory Interneuron Number in the Cortex ' , Cell Reports , vol. 22 , no. 7 , pp. 1710-1721 . https://doi.org/10.1016/j.celrep.2018.01.064 |
| سنة النشر: | 2018 |
| المجموعة: | King's College, London: Research Portal |
| مصطلحات موضوعية: | activity-dependent plasticity, cortical interneurons, DREADS, homeostatic plasticity, interneuron cell death, interneuron development, interneuron transplantations, Lhx6 |
| الوصف: | Cortical networks are composed of excitatory projection neurons and inhibitory interneurons. Finding the right balance between the two is important for controlling overall cortical excitation and network dynamics. However, it is unclear how the correct number of cortical interneurons (CIs) is established in the mammalian forebrain. CIs are generated in excess from basal forebrain progenitors, and their final numbers are adjusted via an intrinsically determined program of apoptosis that takes place during an early postnatal window. Here, we provide evidence that the extent of CI apoptosis during this critical period is plastic and cell-type specific and can be reduced in a cell-autonomous manner by acute increases in neuronal activity. We propose that the physiological state of the emerging neural network controls the activity levels of local CIs to modulate their numbers in a homeostatic manner. Denaxa et al. address how the number of interneurons in the cortex is regulated. They show that apoptosis of developing interneurons can be modulated by activity in the forebrain of young mice so that increases in activity can rescue interneurons from apoptosis. This feedback loop provides a mechanism for fine-tuning the number and repertoire of interneurons in the brain. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.celrep.2018.01.064 |
| الاتاحة: | https://kclpure.kcl.ac.uk/portal/en/publications/103fa03f-c34b-4fd8-9290-e76e32ff9bdc https://doi.org/10.1016/j.celrep.2018.01.064 https://kclpure.kcl.ac.uk/ws/files/97595866/1_s2.0_S221112471830113X_main.pdf http://www.scopus.com/inward/record.url?scp=85041994600&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DC7F44AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.celrep.2018.01.064 |
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