Academic Journal

Inhibitory effects of procainamide on sympathetic nerve activity in humans.

التفاصيل البيبلوغرافية
العنوان: Inhibitory effects of procainamide on sympathetic nerve activity in humans.
المؤلفون: Rea, R F, Hamdan, M, Schomer, S J, Geraets, D R
المصدر: Circulation Research ; volume 69, issue 2, page 501-508 ; ISSN 0009-7330 1524-4571
بيانات النشر: Ovid Technologies (Wolters Kluwer Health)
سنة النشر: 1991
الوصف: In experimental animals, procainamide causes hypotension and reductions in efferent vasoconstrictor sympathetic outflow that may result from ganglionic blockade or central nervous system sympathetic inhibition. To test the hypothesis that procainamide decreases sympathetic nerve activity (SNA) in humans, we recorded postganglionic SNA in seven normal subjects in the baseline state and during infusions of procainamide HCl at 50 mg/min (loading) and 8 mg/min (maintenance). At the end of the loading infusion, mean arterial pressure (MAP) had decreased from 88.5 +/- 2.4 (mean +/- SEM) to 81.5 +/- 3.2 mm Hg (p less than 0.05), central venous pressure from 6.7 +/- 0.7 to 5.4 +/- 0.9 mm Hg (p less than 0.05), forearm vascular resistance (FVR) from 28 +/- 4.8 to 22.3 +/- 5.1 resistance units (p less than 0.05), and SNA from 259 +/- 47 to 94 +/- 26 units/min (p less than 0.05). These changes persisted during the maintenance infusion. Increased levels of SNA, FVR, and MAP provoked by the cold pressor test were reduced significantly by intravenous procainamide. In eight other subjects, intravenous procainamide HCl (15 mg/kg at 50 mg/min) caused dose-dependent inhibition of SNA that reversed as blood concentrations fell during drug washout. To determine if procainamide causes direct vasodilation, in nine subjects, graded infusions were delivered into the brachial artery at doses that produced no systemic effect. Ipsilateral FVR tended to increase during local intra-arterial infusion of procainamide. These data show that intravenous procainamide causes hypotension, vasodilation, and sympathetic withdrawal. Vasodilation does not result from a direct vasorelaxant effect of the drug.(ABSTRACT TRUNCATED AT 250 WORDS)
نوع الوثيقة: article in journal/newspaper
اللغة: English
DOI: 10.1161/01.res.69.2.501
DOI: 10.1161/01.RES.69.2.501
الاتاحة: http://dx.doi.org/10.1161/01.res.69.2.501
https://www.ahajournals.org/doi/pdf/10.1161/01.RES.69.2.501
رقم الانضمام: edsbas.DC5AB807
قاعدة البيانات: BASE