التفاصيل البيبلوغرافية
| العنوان: |
Cost-Effectiveness Analysis of Topical Treatments for Actinic Keratosis in Italian National Health System |
| المؤلفون: |
Mariafrancesca Hyeraci, Gianluca Pistore, Francesco Ricci, Francesco Moro, Giovanni Di Lella, Elena Dellambra, Damiano Abeni, Luca Fania |
| المصدر: |
Journal of Clinical Medicine ; Volume 13 ; Issue 21 ; Pages: 6312 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2024 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
actinic keratosis, cost-effectiveness, Italian healthcare system, 5-fluorouracil, diclofenac, imiquimod, tirbanibulin |
| الوصف: |
Introduction: Actinic keratosis (AK) is a widespread pre-cancerous skin condition that may evolve to squamous cell carcinoma, a non-melanoma skin cancer, which is able to become locally invasive and metastatic. Thus, it is important to treat AK. Methods: We conducted a cost-effectiveness analysis for the field-directed therapeutic approaches: local application of drugs containing 5-fluorouracil, both alone at a 4% concentration and associated to 10% salicylic acid at a 0.5% concentration (0.5% 5-FU + 10% SA cut. sol.); diclofenac-hyaluronic acid gel; imiquimod, both at 3.75% and 5% (5% IMQ cream) concentrations; and tirbanibulin ointment. The effectiveness data were abstracted from the literature. The cost-effectiveness analysis was performed by considering the prices reported by Agenzia Italiana del Farmaco (AIFA) for each medicine. Results: We obtained the total cost for each treatment by computing the cost of a single treatment for its duration. Application of 0.5% 5-FU + 10% SA cut. sol. appeared as the most convenient approach, as it was more effective and less expensive than all treatments except for 5% IMQ cream. For this last option, the incremental cost/effectiveness ratio analysis showed that a modest gain in effectiveness has a cost of EUR 7.94, therefore making it less cost effective. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Dermatology; https://dx.doi.org/10.3390/jcm13216312 |
| DOI: |
10.3390/jcm13216312 |
| الاتاحة: |
https://doi.org/10.3390/jcm13216312 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.DC3DAC36 |
| قاعدة البيانات: |
BASE |