Academic Journal
The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey
| العنوان: | The real-life management of glucose homeostasis abnormalities in pediatric onco-hematological diseases: data from a national survey |
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| المؤلفون: | Zanfardino, Angela, Bruzzi, Patrizia, Trada, Michela, Rapini, Novella, Laudani, Emanuela, Tornese, Gianluca, Ortolani, Federica, Piccolo, Gianluca, Matonti, Lorena, Saltarelli, Maria Alessandra, Timpanaro, Tiziana, D'Annunzio, Giuseppe, Predieri, Barbara, Rossi, Francesca, Mura, Rossella, Barat, Veronica, Prete, Arcangelo, Schiaffini, Riccardo, Zucchini, Stefano |
| المساهمون: | Zanfardino, Angela, Bruzzi, Patrizia, Trada, Michela, Rapini, Novella, Laudani, Emanuela, Tornese, Gianluca, Ortolani, Federica, Piccolo, Gianluca, Matonti, Lorena, Saltarelli, Maria Alessandra, Timpanaro, Tiziana, D'Annunzio, Giuseppe, Predieri, Barbara, Rossi, Francesca, Mura, Rossella, Barat, Veronica, Prete, Arcangelo, Schiaffini, Riccardo, Zucchini, Stefano |
| سنة النشر: | 2024 |
| المجموعة: | Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| مصطلحات موضوعية: | Cancer, children, diabetes mellitu, impaired fasting glycemia, impaired glucose tolerance, thalassemia |
| الوصف: | Glycemic abnormalities are a frequent finding in pediatric oncological patients, both during treatment and after its discontinuation. Moreover, impaired glucose tolerance (IGT), impaired fasting glycemia (IFG) and diabetes mellitus (DM) are not rarely diagnosed in non-oncological hematological diseases. To explore the current pediatric Italian approach to the diagnosis and the management of the glycemic alterations in this clinical setting and, thus, to identify and enforce current clinical needs, we submitted an online 23-items survey to all the Italian Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) centers, and surveys were descriptively analyzed. Thirty-nine AIEOP centers were involved in the study. In 2021, among 75278 children and adolescents affected by an oncological or a hematological disease, 1.2 and 0.65% developed DM, while IGT or IFG were widespread in 2.3 and 2.8%, respectively. The main causes of DM were the use of corticosteroids in patients with cancer and the iron overload in patients with thalassemia. Venous fasting plasma glycemia was the most used tool to detect glycemic abnormalities. The performance of oral glucose tolerance test (OGTT) was extremely limited, except when IFG occurred. Despite the diagnosis of DM, ∼45% of patients with cancer and 30% of patients with one hematological disease did not receive an appropriate treatment. In the other cases, insulin was the drug of first choice. Emerging technologies for diabetes care (glucose sensors and insulin pumps) are not largely used yet. The results of our study support the standardization of the care of the glycemic abnormalities during or after onco-hematologic diseases in the pediatric age. Despite the scarce data in pediatric literature, proper guidelines are needed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38269620; firstpage:1; lastpage:13; numberofpages:13; journal:PEDIATRIC HEMATOLOGY AND ONCOLOGY; https://hdl.handle.net/11368/3067881 |
| DOI: | 10.1080/08880018.2023.2295454 |
| الاتاحة: | https://hdl.handle.net/11368/3067881 https://doi.org/10.1080/08880018.2023.2295454 |
| رقم الانضمام: | edsbas.DC0276B5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1080/08880018.2023.2295454 |
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