Academic Journal
Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity
| العنوان: | Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity |
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| المؤلفون: | Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Silvia Savastano, Alessio Volpe, Marcello Orio, Giorgio Colarieti, Giovanni Battista La Sala, Annamaria Colao, Francesca Marciano, Antonio Ascione, Pietro Putignano |
| المساهمون: | Orio, Francesco, Muscogiuri, Giovanna, Palomba, Stefano, Savastano, Silvia, Volpe, Alessio, Orio, Marcello, Colarieti, Giorgio, Battista La Sala, Giovanni, Colao, Annamaria, Marciano, Francesca, Ascione, Antonio, Putignano, Pietro |
| سنة النشر: | 2013 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | Berberine PCOS Insulin resistance FAI Testosterone BMI |
| الوصف: | Background and aims: Berberine (BBR) is an isoquinoline derivative alkaloid isolated from Rhizoma Coptidis traditionally used as anti diarrheic and, more recently, as hypolipidemic and insulin sensitizer agent. Thus, BBR could represent a potential therapeutic option for patients with polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the clinical, metabolic and hormonal effects of BBR in PCOS women. Methods: Fifty oligoamenorrheic PCOS obese women and 50 age and Body Mass Index (BMI) matched healthy controls were enrolled. PCOS women received BBR treatment (500 mg, 2 times daily) for 6 months. Clinical and biochemical parameters were assessed before and after the treatment period. Results: Total testosterone (p < 0.01), free androgen index (p < 0.01), androstenedione (p < 0.01), sex hormone binding globulin (p < 0.01), progesterone (p < 0.01), total cholesterol (p 0.01), low density lipoprotein cholesterol (p < 0.01), triglycerides (p < 0.01), area under the curve of insulin (p < 0.01), menses frequency (p < 0.01) and Waist Circumference (p 0.04) significantly (p < 0.05) improved after BBR treatment. No correlation was found between variations of insulin sensitivity and hormonal changes. Conclusions: BBR improves clinical, metabolic and reproductive features in PCOS women. Its mechanism of actions need to be elucidated in further studies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | volume:8; issue:5; firstpage:200; lastpage:204; numberofpages:5; journal:E-SPEN JOURNAL; https://hdl.handle.net/11573/1663613 |
| DOI: | 10.1016/j.clnme.2013.07.002 |
| الاتاحة: | https://hdl.handle.net/11573/1663613 https://doi.org/10.1016/j.clnme.2013.07.002 |
| رقم الانضمام: | edsbas.DBF663A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.clnme.2013.07.002 |
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