Academic Journal
Immunological features beyond CD4/CD8 ratio values in older individuals
| العنوان: | Immunological features beyond CD4/CD8 ratio values in older individuals |
|---|---|
| المؤلفون: | Garrido-Rodríguez, Vanesa, Herrero-Fernández, Inés, Castro-Pérez, M. J., Castillo, Ana, Rosado-Sánchez, Isaac, Galvá, M. I., Ramos, Raquel, Olivas-Martínez, Israel, Bulnes-Ramos, Ángel, Cañizares. Julio, Leal, Manuel, Pacheco, Yolanda M. |
| المساهمون: | Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Red Española de Investigación en SIDA |
| بيانات النشر: | Impact Journals |
| سنة النشر: | 2021 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | CD4/CD8 T-cell ratio, Thymic output, Inflammation, Treg, TREC |
| الوصف: | The CD4/CD8 T-cell ratio is emerging as a relevant marker of evolution for many pathologies and therapies. We aimed to explore immunological features beyond CD4/CD8 ratio values in older subjects (>65 years old) who were classified as having lower (<1.4), intermediate (1.4-2), or higher (>2) ratio values. The lower group showed a lower thymic output (sj/β-TREC ratio) and frequency of naïve T-cells, concomitant with increased mature T-cells. In these subjects, the CD4 T-cell subset was enriched in CD95+ but depleted of CD98+ cells. The regulatory T-cell (Treg) compartment was enriched in CTLA-4+ cells. The CD8 T-cell pool exhibited increased frequencies of CD95+ cells but decreased frequencies of integrin-β7+ cells. Interestingly, in the intermediate group, the CD4 pool showed greater differences than the CD8 pool, mostly for cellular senescence. Regarding inflammation, only hsCRP was elevated in the lower group; however, negative correlations between the CD4/CD8 ratio and β2-microglobulin and sCD163 were detected. These subjects displayed trends of more comorbidities and less independence in daily activities. Altogether, our data reveal different thymic output and immune profiles for T-cells across CD4/CD8 ratio values that can define immune capabilities, affecting health status in older individuals. Thus, the CD4/CD8 ratio may be used as an integrative marker of biological age. ; This work was supported by grants from the Fondo de Investigación Sanitaria (FIS; PI18/01216), which is co-funded by Fondos Europeos para el Desarrollo Regional (FEDER) “Una manera de hacer Europa” and the Junta de Andalucía, Consejería de Economía, Innovación, Ciencia y Empleo (Proyecto de Investigación de Excelencia; CTS2593). The Spanish AIDS Research Network of Excellence also supported this study (RD16/0025/0019). V G-R, I O-M and A B-R were supported by Instituto de Salud Carlos III (FI19/00298, CM19/00051 and CD19/00143, respectively). YM. P was supported by the Consejería de Salud y Familias of Junta de Andalucía ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1945-4589 |
| Relation: | Publisher's version; https://doi.org/10.18632/aging.203109; Sí; Aging 13(10): 13443-13459 (2021); http://hdl.handle.net/10261/264425; http://dx.doi.org/10.13039/501100000780; http://dx.doi.org/10.13039/501100004587; http://dx.doi.org/10.13039/501100011011 |
| DOI: | 10.18632/aging.203109 |
| DOI: | 10.13039/501100000780 |
| DOI: | 10.13039/501100004587 |
| DOI: | 10.13039/501100011011 |
| الاتاحة: | http://hdl.handle.net/10261/264425 https://doi.org/10.18632/aging.203109 https://doi.org/10.13039/501100000780 https://doi.org/10.13039/501100004587 https://doi.org/10.13039/501100011011 |
| Rights: | open |
| رقم الانضمام: | edsbas.DBC741F3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19454589 |
|---|---|
| DOI: | 10.18632/aging.203109 |