Academic Journal
Analyzing body composition in living kidney donors:impact on post-transplant kidney function
| العنوان: | Analyzing body composition in living kidney donors:impact on post-transplant kidney function |
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| المؤلفون: | Quint, Evelien E, Westenberg, Lisa B, Nieuwenhuijs-Moeke, Gertrude J, van den Broek, Eva A N, Zorgdrager, Marcel, Viddeleer, Alain R, Bakker, Stephan J L, Nolte, Ija M, van Londen, Marco, Pol, Robert A |
| المصدر: | TransplantLines Investigators , Quint , E E , Westenberg , L B , Nieuwenhuijs-Moeke , G J , van den Broek , E A N , Zorgdrager , M , Viddeleer , A R , Bakker , S J L , Nolte , I M , van Londen , M & Pol , R A 2024 , ' Analyzing body composition in living kidney donors : impact on post-transplant kidney function ' , Frontiers in Nephrology , vol. 4 , 1467669 . https://doi.org/10.3389/fneph.2024.1467669 |
| سنة النشر: | 2024 |
| المجموعة: | University of Groningen research database |
| الوصف: | Living donor kidney transplantation boasts superior patient and graft survival rates compared to deceased donor kidney transplantation. However, the impact of living donor body composition (BC) on post-transplant kidney function remains uncertain. In a cohort of 293 living kidney donor-recipients pairs, we utilized linear mixed model analyses, adjusted for time and including a multiplicative interaction term of time with the donor body composition measure, and found no significant associations between any donor BC measure and the annual change in recipient post-transplantation estimated glomerular filtration rate (eGFR) [donor body mass index (BMI): B=-0.01, 95%CI -0.13; 0.11, p=0.88; donor waist circumference: B=0.02, 95%CI -0.02; 0.06, p=0.38; donor skeletal muscle index: B=-0.02, 95%CI -0.07; 0.04, p=0.63; donor skeletal muscle radiation attenuation: B=-0.002, 95%CI -0.06; 0.06, p=0.96; donor visceral adipose tissue index: B=-0.001, 95%CI -0.02; 0.02, p=0.93; donor subcutaneous adipose tissue index: B=-0.001, 95%CI -0.02; 0.02, p=0.94; donor intramuscular adipose tissue index: B=-0.12, 95%CI -0.29; 0.06, p=0.19; donor total abdominal adipose tissue index: B=-0.001, 95%CI -0.01; 0.01, p=0.89]. Our study suggests that pre-donation BC does not affect post-transplantation recipient eGFR in donor populations with a BMI below 35 kg/m2. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3389/fneph.2024.1467669 |
| الاتاحة: | https://hdl.handle.net/11370/9279e70c-546b-4e55-a37f-dbfaff3a98ba https://research.rug.nl/en/publications/9279e70c-546b-4e55-a37f-dbfaff3a98ba https://doi.org/10.3389/fneph.2024.1467669 https://pure.rug.nl/ws/files/1163914313/fneph-1-1467669_1_.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DBC22EC3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fneph.2024.1467669 |
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