Academic Journal
Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features
| العنوان: | Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features |
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| المساهمون: | Mi-Na Kim, Jong Hee Shin, Heungsup Sung, Kyungwon Lee, Eui-Chong Kim, Namhee Ryoo, Jin-Sol Lee, Sook-In Jung, Kyung Hwa Park, Seung Jung Kee, Soo Hyun Kim, Myung Geun Shin, Soon Pal Suh, Dong Wook 袁쒕춳, Lee, Kyung Won |
| المصدر: | T200902826.pdf |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Aged, Antifungal Agents/pharmacology, Blood/microbiology, Candida/classification, Candida/drug effects, Candida/isolation & purification, Candidiasis/epidemiology, Candidiasis/microbiology, Candidiasis/pathology, Candidiasis/physiopathology, Child, Preschool, Cross Infection/epidemiology, Cross Infection/microbiology, Cross Infection/pathology, Cross Infection/physiopathology, DNA, Fungal/chemistry, Fungal/genetics, Ribosomal/chemistry, Ribosomal/genetics, Ribosomal Spacer/chemistry, Ribosomal Spacer/genetics, Female, Hospitals, University, Humans, Infant, Korea/epidemiology, Male |
| الوصف: | Background. Candida haemulonii, a yeast species that often exhibits antifungal resistance, rarely causes human infection. During 2004-2006, unusual yeast isolates with phenotypic similarity to C. haemulonii were recovered from 23 patients (8 patients with fungemia and 15 patients with chronic otitis media) in 5 hospitals in Korea. Methods. Isolates were characterized using D1/D2 domain and ITS gene sequencing, and the susceptibility of the isolates to 6 antifungal agents was tested in vitro. Results. Gene sequencing of the blood isolates confirmed C. haemulonii group I (in 1 patient) and Candida pseudohaemulonii (in 7 patients), whereas all isolates recovered from the ear were a novel species of which C. haemulonii is its closest relative. The minimum inhibitory concentration (MIC) ranges of amphotericin B, fluconazole, itraconazole, and voriconazole for all isolates were 0.5-32 microg/mL (MIC(50), 1 microg/mL), 2-128 microg/mL (MIC(50), 4 microg/mL), 0.125-4 microg/mL (MIC(50), 0.25 microg/mL), and 0.03-2 microg/mL (MIC(50), 0.06 microg/mL), respectively. All isolates were susceptible to caspofungin (MIC, 0.125-0.25 microg/mL) and micafungin (MIC, 0.03-0.06 microg/mL). All cases of fungemia occurred in patients with severe underlying diseases who had central venous catheters. Three patients developed breakthrough fungemia while receiving antifungal therapy, and amphotericin B therapeutic failure, which was associated with a high MIC of amphotericin B (32 microg/mL), was observed in 2 patients. Conclusions. Candida species that are closely related to C. haemulonii are emerging sources of infection in Korea. These species show variable patterns of susceptibility to amphotericin B and azole antifungal agents ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | e57~e61 |
| اللغة: | unknown |
| تدمد: | 1058-4838 1537-6591 |
| Relation: | CLINICAL INFECTIOUS DISEASES; J00581; OAK-2009-01083; https://ir.ymlib.yonsei.ac.kr/handle/22282913/104423; T200902826; CLINICAL INFECTIOUS DISEASES, Vol.48(6) : 57-61, 2009 |
| DOI: | 10.1086/597108 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/104423 https://doi.org/10.1086/597108 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ |
| رقم الانضمام: | edsbas.DBC1219B |
| قاعدة البيانات: | BASE |
| تدمد: | 10584838 15376591 |
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| DOI: | 10.1086/597108 |