A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases

التفاصيل البيبلوغرافية
العنوان:	A Fluorescent Styrylquinoline with Combined Therapeutic and Diagnostic Activities against Alzheimer's and Prion Diseases
المؤلفون:	Staderini, M, Aulic, S, Hoang, NAT, Gonzalez Ruiz, V, Perez, DI, Cabezas, N, Martinez, A, Martin, MA, Legname, G, Menendez, JC, BARTOLINI, MANUELA, ANDRISANO, VINCENZA, BOLOGNESI, MARIA LAURA
المساهمون:	Staderini, M, Aulic, S, Bartolini, M, Hoang, NAT, Gonzalez-Ruiz, V, Perez, DI, Cabezas, N, Martinez, A, Martin, MA, Andrisano, Legname, G, Menendez, JC, Bolognesi, ML
سنة النشر:	2013
المجموعة:	IRIS Università degli Studi di Bologna (CRIS - Current Research Information System)
مصطلحات موضوعية:	AMYLOID-BETA 1-42 AGGREGATION, PROTEIN MISFOLDING
الوصف:	(E)-6-Methyl-4'-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both A beta and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits A beta self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test).
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	ELETTRONICO
اللغة:	English
Relation:	info:eu-repo/semantics/altIdentifier/wos/WOS:000315182000021; volume:4; firstpage:225; lastpage:229; numberofpages:5; journal:ACS MEDICINAL CHEMISTRY LETTERS; http://hdl.handle.net/11585/151526; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84873977399
DOI:	10.1021/ml3003605
الاتاحة:	http://hdl.handle.net/11585/151526 https://doi.org/10.1021/ml3003605
رقم الانضمام:	edsbas.DB999240
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1021/ml3003605