Academic Journal
Influence of Teas on Phospholipase A2 and Protease Activity in the Context of Blood Hemostasis-Related Processes
| العنوان: | Influence of Teas on Phospholipase A2 and Protease Activity in the Context of Blood Hemostasis-Related Processes |
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| المؤلفون: | Mateus Santos Carapiá, Daniela Aparecida Oliveira, Marcus Vinicius Cardoso Trento, Silvana Marcussi, Tatiane Silva de Abreu, Pedro Henrique Souza Cesar, Mariana Aparecida Braga |
| المصدر: | Brazilian Archives of Biology and Technology, Vol 67 (2024) |
| بيانات النشر: | Instituto de Tecnologia do Paraná (Tecpar) |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | medicinal plants, functional foods, enzymatic inhibitors, toxins as tools, Biotechnology, TP248.13-248.65 |
| الوصف: | Tea is identified as the second most consumed drink in the world, and its frequent intake is related to several benefits to human health, considering its antimutagenic, anticarcinogenic, antimicrobial, anti-inflammatory, antihistamine, diuretic, calming, and above all, antioxidant effects. These effects are often associated with the action of the phenolic compounds contained in these infusions. In Brazil, among the most consumed infusions are the teas of chamomile (Matricaria chamomilla L.), lemongrass (Cymbopogon citratus (D.C.) Stapf), lemon balm (Melissa officinalis L.), anise (Pimpinella anisum L.), yerba mate (Ilex paraguariensis A. St.-Hil), peppermint (Mentha piperita L.), and green/black tea (Camellia sinensis L.). Therefore, said popularity is the reason why the mentioned species were chosen to be evaluated on inflammatory enzymes. The activity of phospholipases A2 was reduced by more than 25% after treatment with black tea and yerba mate. The most significant inhibition of protease activity was observed after incubation with black tea (40.74%), green tea (31.48%) and yerba mate (25.93%). Infusions of black and green tea reduced hemolysis in semisolid and liquid media, and for the latter, reductions of up to 50% of hemolytic activity were observed, indicating an anti-inflammatory potential of the samples. Plasma incubations with green tea, black tea and lemon balm and subsequent addition of venom (1:10 ratio; tea:PBS, v:v) prolonged the coagulation time of citrated plasma by approximately twice compared to the positive control. All controls with pure tea had a thrombolytic character, in higher proportions than the venom control, especially chamomile (273.55% dissolution). Phenolic compounds derived from phenolic acids, flavonoids, and tannins are identified as the main agents that promote the biological effects observed in this study. This is mainly due to their anti-catalytic properties exerted on inflammatory enzymes and as chelating agents of enzymatic co-factors. The evaluated teas showed ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1678-4324 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132024000100302&tlng=en; https://doaj.org/toc/1678-4324; https://doaj.org/article/e3f08b0c34894ec5b714f20a7267c291 |
| DOI: | 10.1590/1678-4324-2024220661 |
| الاتاحة: | https://doi.org/10.1590/1678-4324-2024220661 https://doaj.org/article/e3f08b0c34894ec5b714f20a7267c291 |
| رقم الانضمام: | edsbas.DB38BF74 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16784324 |
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| DOI: | 10.1590/1678-4324-2024220661 |