التفاصيل البيبلوغرافية
| العنوان: |
Effects of Charged Oxime Reactivators on the HK‑2 Cell Line in Renal Toxicity Screening |
| المؤلفون: |
Jiri Handl (9327589), David Malinak (1475035), Jan Capek (9327580), Rudolf Andrys (5988836), Erika Rousarova (10126000), Martina Hauschke (10126003), Lenka Bruckova (9327586), Petr Cesla (10126006), Tomas Rousar (9327601), Kamil Musilek (1476094) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Pharmacology, Marine Biology, Cancer, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, oxime, Renal Toxicity Screening Oxime chol., HK -2 cell line, Charged Oxime Reactivators, K 868, HI |
| الوصف: |
Oxime cholinesterase reactivators (oximes) are used to counteract organophosphate intoxication. Charged oximes are administered via intramuscular or intravenous injection when the majority of dose is unmetabolized and is excreted as urine. In this study, the effects of selected double charged oximes were determined in the HK-2 cell line as a model for renal toxicity screening. Some effects on dehydrogenase activity were found for obidoxime, asoxime (syn. HI-6), K027, and K203. The effects of K868 and K869 were found to be unreliable due to rapid degradation of both chlorinated oximes in the assay medium, resulting for K868 in an isoxazole–pyridinium product. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Effects_of_Charged_Oxime_Reactivators_on_the_HK_2_Cell_Line_in_Renal_Toxicity_Screening/13872289 |
| DOI: |
10.1021/acs.chemrestox.0c00489.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.chemrestox.0c00489.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.DB03E8EF |
| قاعدة البيانات: |
BASE |