Academic Journal
IL-10 synthesis and secretion by peripheral blood mononuclear cells in haemodialysis patients.
| العنوان: | IL-10 synthesis and secretion by peripheral blood mononuclear cells in haemodialysis patients. |
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| المؤلفون: | Brunet, P, Capo, C, Dellacasagrande, J, Thirion, X, Mege, J L, Berland, Y |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1998 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Journal Article |
| الوصف: | PURPOSE OF STUDY: IL-10 may explain the paradox between immunodeficiency and oversecretion of cytokines in chronic haemodialysis (HD) patients. We analysed the secretion of IL-10 by PBMC and the expression of IL-10 mRNA in 10 long-term HD patients (108-276 months), 10 short-term HD patients (3-18 months), and 10 healthy controls. RESULTS: Spontaneous IL-10 secretion was higher in HD patients than in controls (15 pg/ml vs 2 pg/ml, P = 0.004). It was detected in 13 of 20 patients and in 1 of 10 controls (P = 0.01). IL-10 mRNA expression was also higher in HD patients than in controls. Spontaneous secretions of IL-10 and IL-6 were positively correlated in patients. IL-10 secretion in response to LPS was higher than the upper limit of control range in 4 of 10 long-term HD patients and in no short-term HD patients (P = 0.04). IL-10 mRNA expression was also higher in long-term than in short-term HD patients. CONCLUSIONS: This study demonstrates that IL-10 is spontaneously synthesized and secreted in HD patients, supporting an immunomodulating role in this setting. The greater IL-10-producing capacity in long-term HD patients indicates a chronic effect of haemodialysis on PBMC responsiveness. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://ndt.oxfordjournals.org/cgi/content/short/13/7/1745; http://dx.doi.org/10.1093/ndt/13.7.1745 |
| DOI: | 10.1093/ndt/13.7.1745 |
| الاتاحة: | http://ndt.oxfordjournals.org/cgi/content/short/13/7/1745 https://doi.org/10.1093/ndt/13.7.1745 |
| Rights: | Copyright (C) 1998, European Renal Association - European Dialysis and Transplant Association |
| رقم الانضمام: | edsbas.DAE66B71 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ndt/13.7.1745 |
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