التفاصيل البيبلوغرافية
| العنوان: |
Towards precision medicine: defining and characterizing adipose tissue dysfunction to identify early immunometabolic risk in symptom-free adults from the GEMM family study |
| المؤلفون: |
Rodriguez-Ayala, Ernesto, Gallegos-Cabrales, Esther C, Gonzalez-Lopez, Laura, Laviada-Molina, Hugo A, Salinas-Osornio, Rocio A, Nava-Gonzalez, Edna J, Leal-Berumen, Irene, Escudero-Lourdes, Claudia, Escalante-Araiza, Fabiola, Buenfil-Rello, Fatima A, Peschard, Vanessa-Giselle, Laviada-Nagel, Antonio, Silva, Eliud, Veloz-Garza, Rosa A, Martinez-Hernandez, Angelica, Barajas-Olmos, Francisco M, Molina-Segui, Fernanda, Gonzalez-Ramirez, Lucia, Espadas-Olivera, Rebeca, Lopez-Muñoz, Ricardo, Arjona-Villicaña, Ruy D, Hernandez-Escalante, Victor M, Rodriguez-Arellano, Martha E, Gaytan-Saucedo, Janeth F, Vaquera, Zoila, Acebo-Martinez, Monica, Cornejo-Barrera, Judith, Andrea, Huertas-Quintero Jancy, Castillo-Pineda, Juan Carlos, Murillo-Ramirez, Areli, Diaz-Tena, Sara P, Figueroa-Nuñez, Benigno, Valencia-Rendon, Melesio E, Garzon-Zamora, Rafael, Viveros-Paredes, Juan Manuel, Ángeles-Chimal, José, Tapia, Jesús Santa-Olalla, Remes-Troche, José M, Valdovinos-Chavez, Salvador B, Huerta-Avila, Eira E, Lopez-Alvarenga, Juan Carlos, Comuzzie, Anthony G, Haack, Karin, Han, Xianlin, Orozco, Lorena, Weintraub, Susan, Kent, Jack W, Cole, Shelley A, Bastarrachea, Raul A |
| المصدر: |
Adipocyte, vol 9, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2020 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Diabetes, Nutrition, Cardiovascular, Clinical Research, Obesity, Aetiology, 2.1 Biological and endogenous factors, Metabolic and endocrine, Good Health and Well Being, Adipose Tissue, Adult, Cohort Studies, Fasting, Female, Humans, Insulin Resistance, Lipids, Male, Phenotype, Precision Medicine, Risk Factors, Adipose tissue dysfunction, immunometabolism, postprandial tissue biopsies, non-coding microRNAs, shotgun lipidomics |
| جغرافية الموضوع: |
153 - 169 |
| الوصف: |
Interactions between macrophages and adipocytes are early molecular factors influencing adipose tissue (AT) dysfunction, resulting in high leptin, low adiponectin circulating levels and low-grade metaflammation, leading to insulin resistance (IR) with increased cardiovascular risk. We report the characterization of AT dysfunction through measurements of the adiponectin/leptin ratio (ALR), the adipo-insulin resistance index (Adipo-IRi), fasting/postprandial (F/P) immunometabolic phenotyping and direct F/P differential gene expression in AT biopsies obtained from symptom-free adults from the GEMM family study. AT dysfunction was evaluated through associations of the ALR with F/P insulin-glucose axis, lipid-lipoprotein metabolism, and inflammatory markers. A relevant pattern of negative associations between decreased ALR and markers of systemic low-grade metaflammation, HOMA, and postprandial cardiovascular risk hyperinsulinemic, triglyceride and GLP-1 curves was found. We also analysed their plasma non-coding microRNAs and shotgun lipidomics profiles finding trends that may reflect a pattern of adipose tissue dysfunction in the fed and fasted state. Direct gene differential expression data showed initial patterns of AT molecular signatures of key immunometabolic genes involved in AT expansion, angiogenic remodelling and immune cell migration. These data reinforce the central, early role of AT dysfunction at the molecular and systemic level in the pathogenesis of IR and immunometabolic disorders. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| Relation: |
qt2mr8976q; https://escholarship.org/uc/item/2mr8976q |
| الاتاحة: |
https://escholarship.org/uc/item/2mr8976q |
| Rights: |
public |
| رقم الانضمام: |
edsbas.DADDD4AA |
| قاعدة البيانات: |
BASE |