Academic Journal
Glycemic control and adherence to basal insulin therapy in Taiwanese patients with type 2 diabetes mellitus
| العنوان: | Glycemic control and adherence to basal insulin therapy in Taiwanese patients with type 2 diabetes mellitus |
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| المؤلفون: | Chien, Ming‐Nan, Chen, Yen‐Ling, Hung, Yi‐Jen, Wang, Shu‐Yi, Lu, Wen‐Tsung, Chen, Chih‐Hung, Lin, Ching‐Ling, Huang, Tze‐Pao, Tsai, Ming‐Han, Tseng, Wei‐Kung, Wu, Ta‐Jen, Ho, Cheng, Lin, Wen‐Yu, Chen, Bill, Chuang, Lee‐Ming |
| المساهمون: | Sanofi Taiwan Co., Ltd., Formosa Biomedical Technology Corp., CRO |
| المصدر: | Journal of Diabetes Investigation ; volume 7, issue 6, page 881-888 ; ISSN 2040-1116 2040-1124 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aims/Introduction The aim of the present study was to assess the glycemic control, adherence and treatment satisfaction in a real‐world setting with basal insulin therapy in type 2 diabetes patients in Taiwan. Materials and Methods This was a multicenter, prospective, observational registry. A total of 836 patients with type 2 diabetes taking oral antidiabetic drugs with glycated hemoglobin (HbA1c) >7% entered the study. Basal insulin was given for 24 weeks. All treatment choices and medical instructions were at the physician's discretion to reflect real‐life practice. Results After 24‐week treatment, 11.7% of patients reached set HbA1c goals without severe hypoglycemia (primary effectiveness end‐point). HbA1c and fasting blood glucose were significantly decreased from (mean ± SD ) 10.1 ± 1.9% to 8.7 ± 1.7% (−1.4 ± 2.1%, P < 0.0001) and from 230.6 ± 68.8 mg/dL to 159.1 ± 55.6 mg/dL (−67.4 ± 72.3 mg/dL, P < 0.0001), respectively. Patients received insulin therapy at a frequency of nearly one shot per day on average, whereas self‐monitoring of blood glucose was carried out approximately four times a week. Hypoglycemia was reported by 11.4% of patients, and only 0.7% of patients experienced severe hypoglycemia. Slight changes in weight (0.7 ± 2.4 kg) and a low incidence of adverse drug reactions (0.4%) were also noted. The score of 7‐point treatment satisfaction rated by patients was significantly improved by 1.9 ± 1.7 ( P < 0.0001). Conclusions Basal insulin therapy was associated with a decrease in HbA1c and fasting blood glucose, and an improved treatment satisfaction. Most patients complied with physicians' instructions. The treatment was generally well tolerated by patients with type 2 diabetes, but findings pointed out the need to reinforce the early and appropriate uptitration to achieve treatment targets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/jdi.12532 |
| الاتاحة: | http://dx.doi.org/10.1111/jdi.12532 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjdi.12532 https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdi.12532 https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jdi.12532 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.DA8D24B2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/jdi.12532 |
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