Academic Journal
Upfront use of gemtuzumab ozogamicin in young children with CD33‐positive AML
| العنوان: | Upfront use of gemtuzumab ozogamicin in young children with CD33‐positive AML |
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| المؤلفون: | Sayar, Dror, Burstein, Yoav, Bielorai, Bela, Toren, Amos, Dvir, Rina |
| المصدر: | Pediatric Blood & Cancer ; volume 55, issue 1, page 183-185 ; ISSN 1545-5009 1545-5017 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Gemtuzumab ozogamicin (GO) is a humanized anti‐CD33 antibody used for treating patients with CD33+ acute myeloid leukemia (AML). We report three young children (two infants and one toddler) with AML treated with GO 9 mg/m 2 . Two received two doses at diagnosis alone with conventional chemotherapy and one received one dose after relapse. GO was well tolerated and all three achieved remission. All were transplanted: one relapsed after 5 months and died of disease, one died a toxic death in remission due to pulmonary fibrosis, and one survived (41 months from diagnosis). In conclusion, GO was well tolerated in these young patients with evidence for efficacy. Pediatr Blood Cancer 2010;55:183–185. © 2010 Wiley‐Liss, Inc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/pbc.22404 |
| الاتاحة: | http://dx.doi.org/10.1002/pbc.22404 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpbc.22404 https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.22404 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.DA81AF6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/pbc.22404 |
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