Academic Journal
NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter
| العنوان: | NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter |
|---|---|
| المؤلفون: | Thu, Vu Thi, Kim, Hyoung-Kyu, Long, Le Thanh, Lee, Sung-Ryul, Hanh, Tran My, Ko, Tae Hee, Heo, Hye-Jin, Kim, Nari, Kim, Soon Ha, Ko, Kyung Soo, Rhee, Byoung Doo, Han, Jin |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2012 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Original Article |
| الوصف: | Aims Preservation of mitochondrial function is essential to limit myocardial damage in ischaemic heart disease. We examined the protective effects and mechanism of a new compound, NecroX-5, on rat heart mitochondria in a hypoxia/reoxygenation (HR) model. Methods and results NecroX-5 reduced mitochondrial oxidative stress, prevented the collapse in mitochondrial membrane potential, improved mitochondrial oxygen consumption, and suppressed mitochondrial Ca2+ overload during reoxygenation in an in vitro rat heart HR model. Furthermore, NecroX-5 reduced the ouabain- or histamine-induced increase in mitochondrial Ca2+. Conclusion These findings suggest that NecroX-5 may act as a mitochondrial Ca2+ uniporter inhibitor to protect cardiac mitochondria against HR damage. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://cardiovascres.oxfordjournals.org/cgi/content/short/cvs122v2; http://dx.doi.org/10.1093/cvr/cvs122 |
| DOI: | 10.1093/cvr/cvs122 |
| الاتاحة: | http://cardiovascres.oxfordjournals.org/cgi/content/short/cvs122v2 https://doi.org/10.1093/cvr/cvs122 |
| Rights: | Copyright (C) 2012, European Society of Cardiology |
| رقم الانضمام: | edsbas.DA7E3CF2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/cvr/cvs122 |
|---|