Academic Journal
Emergent variant modeling of the serological repertoire to norovirus in young children
| العنوان: | Emergent variant modeling of the serological repertoire to norovirus in young children |
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| المؤلفون: | Lindesmith L.C, Brewer-Jensen P.D, Conrad H, O'Reilly K.M, Mallory M.L, Kelly D, Williams R, Edmunds W.J, Allen D.J, Breuer J, Baric R.S |
| المصدر: | Cell Reports Medicine, 4(3) |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2023 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | variants of concern, antigenic cartography, norovirus, antigenic seniority, immune imprinting, blockade antibodies, neutralizing antibodies |
| الوصف: | Human norovirus is the leading cause of acute gastroenteritis. Young children and the elderly bear the greatest burden of disease, representing more than 200,000 deaths annually. Infection prevalence peaks at younger than 2 years and is driven by novel GII.4 variants that emerge and spread globally. Using a surrogate neutralization assay, we characterize the evolution of the serological neutralizing antibody (nAb) landscape in young children as they transition between sequential GII.4 pandemic variants. Following upsurge of the replacement variant, antigenic cartography illustrates remodeling of the nAb landscape to the new variant accompanied by improved nAb titer. However, nAb relative avidity remains focused on the preceding variant. These data support immune imprinting as a mechanism of immune evasion and GII.4 virus persistence across a population. Understanding the complexities of immunity to rapidly evolving and co-circulating viral variants, like those of norovirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), and dengue viruses, will fundamentally inform vaccine design for emerging pathogens. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.17615/2xax-mc70; https://cdr.lib.unc.edu/downloads/qj72pk28g?file=thumbnail; https://cdr.lib.unc.edu/downloads/qj72pk28g |
| DOI: | 10.17615/2xax-mc70 |
| الاتاحة: | https://doi.org/10.17615/2xax-mc70 https://cdr.lib.unc.edu/downloads/qj72pk28g?file=thumbnail https://cdr.lib.unc.edu/downloads/qj72pk28g |
| رقم الانضمام: | edsbas.DA09F5E0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/2xax-mc70 |
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