التفاصيل البيبلوغرافية
| العنوان: |
Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries |
| المؤلفون: |
Muriel Coupaye, Karlijn Pellikaan, Anthony P. Goldstone, Antonino Crinò, Graziano Grugni, Tania P. Markovic, Charlotte Høybye, Assumpta Caixàs, Helena Mosbah, Laura C. G. De Graaff, Maithé Tauber, Christine Poitou |
| المصدر: |
Journal of Clinical Medicine; Volume 10; Issue 16; Pages: 3555 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Prader–Willi syndrome, hyponatremia, excessive fluid intake, syndrome of inappropriate antidiuretic hormone, desmopressin |
| الوصف: |
In Prader–Willi syndrome (PWS), conditions that are associated with hyponatremia are common, such as excessive fluid intake (EFI), desmopressin use and syndrome of inappropriate antidiuretic hormone (SIADH) caused by psychotropic medication. However, the prevalence of hyponatremia in PWS has rarely been reported. Our aim was to describe the prevalence and severity of hyponatremia in PWS. In October 2020, we performed a retrospective study based on the medical records of a large cohort of children and adults with PWS from seven countries. Among 1326 patients (68% adults), 34 (2.6%) had at least one episode of mild or moderate hyponatremia (125 ≤ Na < 135 mmol/L). The causes of non-severe hyponatremia were often multi-factorial, including psychotropic medication in 32%, EFI in 24% and hyperglycemia in 12%. No obvious cause was found in 29%. Seven (0.5%) adults experienced severe hyponatremia (Na < 125 mmol/L). Among these, five recovered completely, but two died. The causes of severe hyponatremia were desmopressin treatment for nocturnal enuresis (n = 2), EFI (n = 2), adrenal insufficiency (n = 1), diuretic treatment (n = 1) and unknown (n = 1). In conclusion, severe hyponatremia was very rare but potentially fatal in PWS. Desmopressin treatment for nocturnal enuresis should be avoided. Enquiring about EFI and monitoring serum sodium should be included in the routine follow-ups of patients with PWS. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Endocrinology & Metabolism; https://dx.doi.org/10.3390/jcm10163555 |
| DOI: |
10.3390/jcm10163555 |
| الاتاحة: |
https://doi.org/10.3390/jcm10163555 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.D9E1C0EF |
| قاعدة البيانات: |
BASE |