Academic Journal
Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications
| العنوان: | Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications |
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| المؤلفون: | Pathak, Atul, Rudolph, Ulrike M., Saxena, Manish, Zeller, Thomas, Müller-Ehmsen, Jochen, Lipsic, Erik, Schmieder, Roland E., Sievert, Horst, Halbach, Marcel, Sharif, Faisal, Parise, Helen, Fischell, Tim A., Weber, Michael A., Kandzari, David E., Mahfoud, Felix |
| المصدر: | Pathak , A , Rudolph , U M , Saxena , M , Zeller , T , Müller-Ehmsen , J , Lipsic , E , Schmieder , R E , Sievert , H , Halbach , M , Sharif , F , Parise , H , Fischell , T A , Weber , M A , Kandzari , D E & Mahfoud , F 2023 , ' Alcohol-mediated renal denervation in patients with hypertension in the absence of antihypertensive medications ' , Eurointervention , vol. 19 , no. 7 , pp. 602-611 . https://doi.org/10.4244/EIJ-D-23-00088 |
| سنة النشر: | 2023 |
| المجموعة: | University of Groningen research database |
| الوصف: | BACKGROUND: Ultrasound and radiofrequency renal denervation (RDN) have been shown to safely lower blood pressure (BP) in hypertension. AIMS: The TARGET BP OFF-MED trial investigated the efficacy and safety of alcohol-mediated renal denervation (RDN) in the absence of antihypertensive medications. METHODS: This randomised, blinded, sham-controlled trial was conducted in 25 centres in Europe and the USA. Patients with a 24-hour systolic BP of 135-170 mmHg, an office systolic BP 140-180 mmHg and diastolic BP ≥90 mmHg on 0-2 antihypertensive medications were enrolled. The primary efficacy endpoint was the change in mean 24-hour systolic BP at 8 weeks. Safety endpoints included major adverse events up to 30 days. RESULTS: A total of 106 patients were randomised; the baseline mean office BP following medication washout was 159.4/100.4±10.9/7.0 mmHg (RDN) and 160.1/98.3±11.0/6.1 mmHg (sham), respectively. At 8 weeks post-procedure, the mean (±standard deviation) 24-hour systolic BP change was â2.9±7.4 mmHg (p=0.009) versus â1.4±8.6 mmHg (p=0.25) in the RDN and sham groups, respectively (mean between-group difference: 1.5 mmHg; p=0.27). There were no differences in safety events between groups. After 12 months of blinded follow-up, with medication escalation, patients achieved similar office systolic BP (RDN: 147.9±18.5 mmHg; sham: 147.8±15.1 mmHg; p=0.68) with a significantly lower medication burden in the RDN group (mean daily defined dose: 1.5±1.5 vs 2.3±1.7; p=0.017). CONCLUSIONS: In this trial, alcohol-mediated RDN was delivered safely but was not associated with significant BP differences between groups. Medication burden was lower in the RDN group up to 12 months. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.4244/EIJ-D-23-00088 |
| الاتاحة: | https://hdl.handle.net/11370/33fbf244-cf77-4a02-a336-9f59af877175 https://research.rug.nl/en/publications/33fbf244-cf77-4a02-a336-9f59af877175 https://doi.org/10.4244/EIJ-D-23-00088 http://www.scopus.com/inward/record.url?scp=85171601373&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.D9D43DEE |
| قاعدة البيانات: | BASE |
| DOI: | 10.4244/EIJ-D-23-00088 |
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