Academic Journal
Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia
| العنوان: | Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia |
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| المؤلفون: | Militello, Maria Angela, Re, Maria Paola, Vitaliti, Giuliana, Finazzo, Francesca, Manzoni, Paolo, Vitaliti, Salvino Marcello |
| المصدر: | American Journal of Perinatology ; volume 36, issue S 02, page S134-S138 ; ISSN 0735-1631 1098-8785 |
| بيانات النشر: | Georg Thieme Verlag KG |
| سنة النشر: | 2019 |
| الوصف: | Objective Subcutaneous fat necrosis (SCFN) is a rare condition that may occur in the neonatal period. SCFN is an inflammatory disorder of the adipose tissue, usually found in full-term healthy infants who have a history of intrauterine or perinatal distress. It is usually a self-limited condition; however, in some cases, it can get complicated, leading to severe hypercalcemia that may be life-threatening. Study Design We report and describe a classic presentation of SCFN that led to severe hypercalcemia refractory to standard treatment. The diagnosis of SCFN was made based on the finding of subcutaneous nodules and of hypercalcemia. The serum calcium level reached 16.6 mg/dL. Hypercalcemia was treated first with intravenous infusions of fluids and furosemide and then of methylprednisolone. This standard treatment was not effective; therefore, we administered a single low dose of zoledronic acid, which, in turn, was efficacious in ultimately managing the hypercalcemia. Conclusion Our case shows how a single low dose of zoledronic acid was safe and effective in managing severe hypercalcemia unresponsive to conventional treatment while minimizing the risk of hypocalcemic rebounds. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1055/s-0039-1691777 |
| DOI: | 10.1055/s-0039-1691777.pdf |
| الاتاحة: | http://dx.doi.org/10.1055/s-0039-1691777 http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0039-1691777.pdf |
| رقم الانضمام: | edsbas.D9B830E1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1055/s-0039-1691777 |
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