التفاصيل البيبلوغرافية
| العنوان: |
1992 Harwood Academic Publishers GmbH Printed in the United Kingdom PHARMACOKINETICS OF MITOMYCIN C FOLLOWING HEPATIC ARTERIAL CHEMOEMBOLIZATION WITH GELFOAM |
| المؤلفون: |
Jin Wen Ding, Zai De Wu, Roland Andersson |
| المساهمون: |
The Pennsylvania State University CiteSeerX Archives |
| المصدر: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/41/fc/HPB_Surg_1992_5(3)_161-169.tar.gz |
| سنة النشر: |
1991 |
| المجموعة: |
CiteSeerX |
| الوصف: |
Twelve mongrel dogs were randomly allocated into two groups using matched paired-design. Catheters were inserted into the hepatic artery, hepatic vein and the femoral vein, respectively. In the first group, gelfoam supplemented with mitomycin C (MMC) was injected into the hepatic artery, whereas the second group received a hepatic arterial injection of MMC solution alone. Simultaneous blood sampling from the hepatic and femoral veins at regular intervals was performed. MMC concentrations in plasma was determined using high performance liquid chromatography (HPLC) and the pharmacokinetics of MMC were determined. MMC concentrations in hepatic and femoral veins did not differ and no significant difference in pharmacokinetics was found when comparing MMC administration into the hepatic artery with or without gelfoam supplementation. Thus, our results revealed that gelfoam could not delay the clearance of MMC from the liver. KEY WORDS: Mitomycin C, chemoembolization, hepatic artery, liver circulation, pharmacokinetic |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/zip |
| اللغة: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2708 |
| الاتاحة: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.2708 |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: |
edsbas.D996169A |
| قاعدة البيانات: |
BASE |