Academic Journal
Modelling environmental factors correlated with podoconiosis
| العنوان: | Modelling environmental factors correlated with podoconiosis |
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| المؤلفون: | Molla, Yordanos B, Wardrop, Nicola A, Le Blond, Jennifer S, Baxter, Peter, Newport, Melanie J, Atkinson, Peter M, Davey, Gail |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2014 |
| المجموعة: | University of Sussex: Sussex Research Online |
| مصطلحات موضوعية: | QE0001 General Including geographical divisions, RB151 Theories of disease. Etiology. Pathogenesis |
| الوصف: | Introduction: The precise trigger of podoconiosis ─ endemic non-filarial elephantiasis of the lower legs ─ is unknown. Epidemiological and ecological studies have linked the disease with barefoot exposure to red clay soils of volcanic origin. Histopathology investigations have demonstrated silicon, aluminium, magnesium and iron in the lower limb lymph node macrophages of both patients and non-patients living barefoot on these clays. We studied the spatial variation (variations across an area) in podoconiosis prevalence and the associated environmental factors with the goal of better understanding the pathogenesis of podoconiosis. Methods: Fieldwork was conducted from June 2011 to February 2013 in 12 kebeles (administrative units) in northern Ethiopia. Geo-located prevalence data and soil samples were collected and analysed along with secondary geological, topographic, meteorological and elevation data. Soil data were analysed for chemical composition, mineralogy and particle size; and interpolated to provide spatially continuous information. Exploratory, spatial, univariate and multivariate regression analyses of podoconiosis prevalence were conducted in relation to primary (soil) and secondary (elevation, precipitation, and geology) covariates. Results: Podoconiosis distribution showed spatial correlation with variation in elevation and precipitation. Exploratory analysis identified that phyllosilicate minerals, particularly of the clay (smectite and kaolinite) and mica groups, quartz (crystalline silica), iron oxide, and zirconium were associated with podoconiosis prevalence. The final multivariate model showed that smectite (RR = 2.76, 95 % CI: 1.35, 5.73; p = 0.007), quartz (RR = 1.16, 95 % CI: 1.06, 1.26; p = 0.001) and mica (RR = 1.09, 95 % CI: 1.05, 1.13; p < 0.001) had positive associations with podoconiosis prevalence. Conclusions: Smectite, mica and quartz content of the soil was associated with podoconiosis prevalence. Together with previous work indicating that these minerals may influence water ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/msword; application/pdf |
| اللغة: | English |
| Relation: | http://sro.sussex.ac.uk/id/eprint/48948/1/Accepted_MS_BMC_Health_Geo_June2014.doc; http://sro.sussex.ac.uk/id/eprint/48948/3/1476-072X-13-24.pdf; Molla, Yordanos B, Wardrop, Nicola A, Le Blond, Jennifer S, Baxter, Peter, Newport, Melanie J, Atkinson, Peter M and Davey, Gail (2014) Modelling environmental factors correlated with podoconiosis. International Journal of Health Geographics, 13 (24). ISSN 1476-072X |
| DOI: | 10.1186/1476-072X-13-24 |
| الاتاحة: | http://sro.sussex.ac.uk/id/eprint/48948/ http://sro.sussex.ac.uk/id/eprint/48948/1/Accepted_MS_BMC_Health_Geo_June2014.doc http://sro.sussex.ac.uk/id/eprint/48948/3/1476-072X-13-24.pdf https://doi.org/10.1186/1476-072X-13-24 |
| Rights: | cc_by |
| رقم الانضمام: | edsbas.D99029E6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1476-072X-13-24 |
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