Academic Journal
Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments
| العنوان: | Development of Methotrexate Complexes Endowed with New Biological Properties Envisioned for Musculoskeletal Regeneration in Rheumatoid Arthritis Environments |
|---|---|
| المؤلفون: | Fernández-Villa, Daniel, Ramírez-Jiménez, Rosa Ana, Aranaz, Inmaculada, Acosta, Niuris, Vázquez-Lasa, Blanca, Rojo, Luis |
| المساهمون: | Ministerio de Ciencia e Innovación (España) |
| بيانات النشر: | Molecular Diversity Preservation International |
| سنة النشر: | 2022 |
| المجموعة: | Digital.CSIC (Consejo Superior de Investigaciones Científicas / Spanish National Research Council) |
| مصطلحات موضوعية: | methotrexate, strontium, zinc, magnesium, glycosaminoglycans, nitric oxide, antiinflammatory properties, chitosan, microparticles |
| الوصف: | Methotrexate (MTX) administration is the gold standard treatment for rheumatoid arthritis (RA), but its effects are limited to preventing the progression of the disease. Therefore, effective regenerative therapies for damaged tissues are still to be developed. In this regard, MTX complexes of general molecular formula M(MTX)·xHO, where M = Sr, Zn, or Mg, were synthesized and physicochemically characterized by TGA, XRD, NMR, ATR–FTIR, and EDAX spectroscopies. Characterization results demonstrated the coordination between the different cations and MTX via two monodentate bonds with the carboxylate groups of MTX. Cation complexation provided MTX with new bioactive properties such as increasing the deposition of glycosaminoglycans (GAGs) and alternative anti-inflammatory capacities, without compromising the immunosuppressant properties of MTX on macrophages. Lastly, these new complexes were loaded into spray-dried chitosan microparticles as a proof of concept that they can be encapsulated and further delivered in situ in RA-affected joints, envisioning them as a suitable alternative to oral MTX therapy. ; This research has been funded by the Spanish MICINN (MAT201573656-JIN; PID2020- 114086RB-100 and PID2019-105337RB-C22). D.F.-V. is financially supported by a predoctoral program MICINN FPU18/04683. B.V.-L. and L.R. are members of the Interdisciplinary Platform SusPlast+, CSIC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1422-0067 |
| Relation: | #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO//MAT2015-73656-JIN/ES/DESARROLLO DE HIDROGELES BIOMIMETICOS Y ANDAMIOS TISULARES PARA INGENIERIA DE TEJIDOS DEL MUSCULOESQUELETO/; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-114086RB-I00/ES/DESARROLLOS BASADOS EN POLIFENOLES PARA RETOS CLINICOS EN MEDICINA REGENERATIVA PENDIENTES DE RESOLVER /; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-105337RB-C22/ES/QUITOSANOS ESPECIFICOS: DESDE LA SINTESIS SOSTENIBLE DE LOS POLIMEROS HASTA EL DISEÑO DE MATERIALES INTELIGENTES PARA APLICACIONES BIOMEDICAS/; Publisher's version; http://dx.doi.org/10.3390/ijms231710054; Sí; International Journal of Molecular Sciences 23 (2022); http://hdl.handle.net/10261/284912; http://dx.doi.org/10.13039/501100004837 |
| DOI: | 10.3390/ijms231710054 |
| DOI: | 10.13039/501100004837 |
| الاتاحة: | http://hdl.handle.net/10261/284912 https://doi.org/10.3390/ijms231710054 https://doi.org/10.13039/501100004837 |
| Rights: | open |
| رقم الانضمام: | edsbas.D966AAA1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
|---|---|
| DOI: | 10.3390/ijms231710054 |